代谢综合征各组分与老年人糖尿病关系的队列研究

目的 分析老年人代谢综合征(MS)及各组分与2型糖尿病(DM)发生的关系. 方法 队列研究,2007年对2001年参加调查的人群进行随访.用2005年国际DM联盟(IDF)颁布的全球统一标准诊断MS. 结果 基线MS与DM发生密切相关,RR(95% CI)为4.70(3.23～6.85).MS各组分与DM相关性最密切的是空腹血糖.单因素分析中.当血糖水平≥5.60 mmol/L时,RR(95% CI)高达9.68(6.59～14.23);在多因素分析中,当血糖水平为5.60～6.09 mmol/L时,RR值(95% CI)为5.49(3.38～8.92),而≥6.1 mmol/L时,RR值(95% CI)增大至14.44(9.29～22.44).当MS组分聚集数从1、2、3、4个上升到5个时,RR值可分别从2.92、5.67、12.28、19.52上升至37.83. 结论 MS增加患DM的风险,而空腹血糖增高同为DM发生重要的危险指标.

The cohort study of components of metabolic syndrome related with diabetes mellitus in elderly patients

Objective To analyze the correlation of metabolic syndrome (MS) and its components with a future development of diabetes mellitus (DM) in elderly patients. Methods In 2007, the cohort study was carried out among the 2001 baseline population. The criteria which was proposed by international diabetes federation in 2005 was referred to diagnose MS. Results MS predicted the future development of DM (RR = 4. 70, 95% CI:3.23～6.85). Among MS components, fasting glucose exhibited the highest association with DM. The univariate analysis showed that while fasting glucose was more than 5. 6 mmol/L, the RR(95% CD was 9. 68(6. 59～ 14.23). And multiple factors analysis showed that while fasting glucose was 5.60 mmol/L～6. 09 mmol/L, the RR(95% CD was 5. 49(3. 38～8. 92). While glucose level was more than 6. 1 but less than 7.0 mmol/L, the RR(95% CI) increased to 14.44(9.29～22.44). However, along with the increasing of cluster number of MS components from 1,2,3,4 to 5, the corresponding RR increased from 2. 92, 5. 67, 12. 28, 19. 52 to 37. 83. Conclusions MS increases the risk of DM. Among MS components, fasting glucose level is the strongest risk indicator of DM.