聚乙烯醇改性医用壳聚糖微球的制备及其血脂吸附实验

目的：制备性能优良的医用壳聚糖微球，用于吸附血脂。方法：以壳聚糖为原料，液体石蜡为悬浮介质，加入适量的交联剂戊二醛和少量的改性剂聚乙烯醇(PVA)，采用悬浮交联工艺，制备壳聚糖微球，采用动态法进行血脂吸附。结果：加入少量PVA制成的壳聚糖微球更有利于吸附血脂中低密度脂蛋白(LDL)、总胆固醇(TC)、甘油三酯(TG)。结论：加入少量改性剂PVA的壳聚糖微球有望成为性能优良的、能选择性吸附血脂的医用微球。

Preparation of medical chitosan microspheres improved with polyvinyl alcohol and its adsorption test of blood lipids

Objective To prepare medical chitosan microspheres used in blood lipid adsorption. Methods Medical chitosan microspheres were prepared by suspending chitosan in liquid paraffin, adding proportional glutaraldehyde as crosslinking agent and a small amount of polyvinyl alcohol(PVA) to improve its flexibility. The blood lipid adsorption v/ere studied in a dynamic way. Results The medical chitosan microspheres containing a small amount of PVA were more effective in decreasing the contents of cholesterol(CH) , triglyceride(TG) , LDL in human serum. Conclusion The chitosan microspheres obtained by adding a small amount of PVA could be used as a desirable medical microsphere in the adsorption of blood lipids.