| 氨格鲁米特治疗不同雌激素受体状态的复发转移乳腺癌 |
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| 引用本文： | 宋三泰,汤仲明,苏燕燕,田跃,张友仁,张伟京,刘秀文,王桂山.氨格鲁米特治疗不同雌激素受体状态的复发转移乳腺癌[J].中国新药与临床杂志,1988(2). |
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| 作者姓名： | 宋三泰 汤仲明 苏燕燕 田跃 张友仁 张伟京 刘秀文 王桂山 |
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| 作者单位： | 军事医学科学院附属307医院，军事医学科学院放射医学研究所，军事医学科学院附属307医院，军事医学科学院附属307医院，军事医学科学院附属307医院，军事医学科学院附属307医院，军事医学科学院放射医学研究所，军事医学科学院放射医学研究所 北京100039，北京100039，北京100039，北京100039，北京100039 |
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| 摘 要： | 氨格鲁米特治疗不同ER状态的复发转移乳腺癌29例次,口服剂量为0.25g,qid。持续用药1mo以上。结果表明对ER阳性乳腺癌的有效率为7/15(47％),ER阴性为0/14(p<0.05)。ER阳性乳腺癌中以首次复发转移的病人,骨及软组织病灶的效果相对较好。其副反应不严重,极少需要停药,多可自行消失。临床应用时应通过ER检查,提高治疗的合理性。
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| 关 键 词： | 乳腺肿瘤 氨格鲁米特 雌激素受体 抗肿瘤药 氢可的松 |
Aminoglutethimide in therapy of advanced breast cancer with respect to estrogen receptor status |
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| SONG San-Tai,TANG Zhong-Ming,SU Yan-Yan,TIAN Yue,ZHANG You-Ren,ZHANG Wei-Jing,LIU Xiu-Wen,WANG Gui-Shan.Aminoglutethimide in therapy of advanced breast cancer with respect to estrogen receptor status[J].Chinese Journal of New Drugs and Clinical Remedies,1988(2). |
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| Authors: | SONG San-Tai TANG Zhong-Ming SU Yan-Yan TIAN Yue ZHANG You-Ren ZHANG Wei-Jing LIU Xiu-Wen WANG Gui-Shan |
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| Abstract: | Aminoglutethimide was given po 250 mg qid and hydrocortisone po 50 mg bid for more than 1 month (29 courses in 27 oatients). The estrogen receptors (ER) were measured by 3H estradiol binding method. The overall objective response rates(complete and partial remissions)in ER positive and negative groups were 7/15 and 0/14, respectively (p<0.05). In respect of the locations the response rates were: soft tissue 5/9, bone 4/10, and viscera 0/4. The response rate in first relapse of me'tastatic cancer(4/4) seemed to be slightly higher (p>0.05) than that in recur-rences(3/11).The adverse reactions were mild.The value of ER determination in therapy of breast cancer is emphasized. |
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| Keywords: | aminoglutethimide breast neoplasms estrogen receptors antmeoplas-tic agents hydrocortisone |
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