| 实验性变态反应性神经炎周围神经浸润CD4(+)T细胞的凋亡 |
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| 引用本文： | 彭永,肖波,冯德云,杨欢,资小宏,谢光洁. 实验性变态反应性神经炎周围神经浸润CD4(+)T细胞的凋亡[J]. 中南大学学报(医学版), 1999, 24(6): 536-538 |
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| 作者姓名： | 彭永 肖波 冯德云 杨欢 资小宏 谢光洁 |
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| 作者单位： | 第三附属医院神经内科,长沙,410013 |
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| 摘 要： | 为探讨实验性变态反应性神经炎(EAN) 中周围神经浸润CD4( + ) T细胞的凋亡,应用免疫组织化学和原位末端标记法动态检测不同发病阶段EAN 大鼠坐骨神经浸润CD4( + ) T 细胞的形态学改变及断裂的DNA 片段。结果发现具有凋亡形态学特征的浸润CD4( + ) T 细胞于免疫后第18 d 出现,在第22 d 达高峰后下降,第30 d 基本消失。原位末端标记法证实凋亡CD4( + ) T 细胞中存在断裂的DNA 片段。提示CD4( + ) T细胞凋亡是EAN 浸润CD4( + ) T细胞的重要清除机制
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| 关 键 词： | 神经炎,实验性变应性 T淋巴细胞亚群 细胞凋亡 周围神经 免疫组织化学 原位末端标记法 疾病模型,动物 大鼠,Wistar |
Apoptosis of CD4(+) T cells during experimental autoi mmune neuritis in Wistar rats |
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| Peng Yong,Xiao Bo,Feng Deyun,Yang Huan,Zi Xiaohong,Xie Guangjie. Apoptosis of CD4(+) T cells during experimental autoi mmune neuritis in Wistar rats[J]. Journal of Central South University. Medical sciences, 1999, 24(6): 536-538 |
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| Authors: | Peng Yong Xiao Bo Feng Deyun Yang Huan Zi Xiaohong Xie Guangjie |
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| Abstract: | The present study describes apoptosis of T cells in the sciatic nerve in Wistar rats with experimental autoimmune neuritis(EAN). Morphological characterizations of apoptosis were found at the 18th day from onset, peaked at the 22nd day by immunocytochemical analysis. In situ end labeling(ISEL) techniques confirmed the presence of DNA fragmentation in CD4(+) T cells. It is suggested that apoptosis is an important clearance mechanism of infiltrated T cells in the peripheral nervous system(PNS) in EAN. |
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| Keywords: | neuritis experimental allergic cell apoptosis lymphocyte subsets peripheral nerve in situ end labeling immunohistochemistry disease models animal rats Wistar |
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