四种引产方法随机比较及其血前列腺素E水平的观察分析

目的 前瞻性对照组研究４种引产方法的时效及对母儿的影响，了解血前列腺素Ｅ水平变化与引产方式的关系。方法 将１２４足月单胎头位具有引产指征、宫颈评分≤４分的孕妇随机分组，其中催产素组２８例，水囊组２８例，米索前列醇组２５例，前列腺素Ｅ２凝胶组４３例。各种方法使用后如宫颈评分≥７分则行人工破膜。各组产妇在用药前、用药后６小时、宫口开全分别取血，用放免法查血ＰＧＥ水平。统计学分析引产时效、母儿并发症及血

A randomized comparison of four methods for induced labor and analysis of the concentration of prostaglandin E in each group

Objective To compare the efficiency of four different methods of induced labor and their related maternal and infant complications.To analyze changes in the concentration of prostaglandin E in the plasma of each group studied.Methods A total of 124 term singleton vertex fetus pregnancies were randomly distributed to one of the four induced labor methods,and these women all showed a Bishop score of less than or equal to 4.The four methods were:continuous intravenus oxytocin drip;water balloon device;intravaginal misoprostol and intracervical prostaglandin E gel.Once the Bishop score exceeded 7,an artificial amniotomy was performed.Venous blood samples were taken prior to and at the time when cervical dilation reach 3cm and 10cm to test the concentration of prostaglandin E.Results No significant differences in maternal or fetal complications were observed among the four group.The intervals from the beginning of induced labor to the time when the cervix had dilated to 3cm of the misoprostol group and prostaglandin E group were much shorter than the other two groups.Conclusion Both prostaglandin E-1 and E-2 have great effect in helping the dilation of cervix and shortening the interval of the labor.While water balloon device is economical and reliable,the intravenous oxytocin drip is being replaced by the other methods.