儿童感染性疾病凝血指标检测的临床意义 |
| |
作者单位: | 上海交通大学医学院附属新华医院上海儿童医学中心实验诊断中心 上海200127 |
| |
摘 要: | 目的探讨儿童感染性疾病中,凝血功能变化对感染的诊断及转归的意义。方法取患儿感染期标本,分别以凝固法、发色底物法、免疫胶体金法等检测凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原含量(FIB)、凝血酶时间(TT)、抗凝血酶活性(AT:A)、D-二聚体(DD)等凝血及抗凝指标。结果感染患儿的凝血指标与正常对照组儿童间差异有统计学意义,特别是AT:A与DD的结果在弥散性血管内凝血(D IC)组与非D IC组中差异有统计学意义。结论各凝血指标特别是AT:A和DD的检测可作为D IC前期诊断和预后评估的指标。
|
关 键 词: | 凝血 感染 弥散性血管内凝血 抗凝血酶活性 D-二聚体 |
Clinical significance of the coagulation parameter in children with infectious disease |
| |
Authors: | WANG Jing SHEN Lisong |
| |
Abstract: | Objective To investigate the dynamic changes of the coagulation function in children with infectious disease and its prognosis significance. Methods Blood levels of prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB),thrombin time(TT),antithrombin activity(AT:A) and D-Dimer(DD) were tested by coagulation method,color substrate method and immunological colloidal gold method. Results The levels of these parameters were significantly different between the infected children and the normal children,especially AT:A and DD were distinguished between disseminated intravascular coagulation(DIC) group and non-DIC group. Conclusions Coagulation parameters,especial AT:A and DD,may be used for early diagnosis of Pre-DIC and evaluation of the prognosis. |
| |
Keywords: | Coagulation Infection Disseminated intravascular coagulation Antithrombin activity D-Dimer |
本文献已被 CNKI 等数据库收录! |
|