| 小鼠异位心脏移植模型的建立 |
| |
| 引用本文： | 倪一鸣,冯强,梁宏立. 小鼠异位心脏移植模型的建立[J]. 中华器官移植杂志, 2002, 23(6): 339-340 |
| |
| 作者姓名： | 倪一鸣 冯强 梁宏立 |
| |
| 作者单位： | 310003,杭州,浙江大学医学院附属第一医院心胸外科,浙江省器官移植中心 |
| |
| 基金项目： | 浙江省自然科学研究基金资助项目 ( 4 910 10 N2 0 0 86 ) |
| |
| 摘 要： | 目的：利用优良的小鼠品系，建立小鼠异位心脏移植模型，以优化实验条件，降低实验成本。方法：借大鼠腹内心脏移植Ono术式，将NIH小鼠40只随机分为供、受者，供者心脏的升主动脉和肺动脉分别与受者腹主动脉和下腔静脉行端侧吻合，成功地建立了小鼠异位心脏移植模型。结果：手术操作简便，技术可靠；小鼠异位心脏移植成功16例，失败4例，成功率达80％。结论：该模型的建立，为进一步进行移植及免疫学方面的研究奠定了良好的基础。
|
| 关 键 词： | 小鼠 异位心脏移植 免疫学 手术方式 |
Establishment of heterotopic heart transplantation in mice |
| |
| NI Yiming,FENG Qiang,LIANG Hongli. Thoracic-cardiovascular Surgery The FirstAffiliated Hospital of Zhejiang University Medical School,Hangzhou ,China. Establishment of heterotopic heart transplantation in mice[J]. Chinese Journal of Organ Transplantation, 2002, 23(6): 339-340 |
| |
| Authors: | NI Yiming FENG Qiang LIANG Hongli. Thoracic-cardiovascular Surgery The FirstAffiliated Hospital of Zhejiang University Medical School Hangzhou China |
| |
| Affiliation: | NI Yiming,FENG Qiang,LIANG Hongli. Thoracic-cardiovascular Surgery The FirstAffiliated Hospital of Zhejiang University Medical School,Hangzhou 310003,China |
| |
| Abstract: | Objective To establish the animal model of heterotopic heart transplantation in mice. Methods According to the surgical procedures of Ono's pattern in mice model, 40 NIH mice were randomly divided into donors and recipients. The ascending artery and pulmonary artery of the donor's heart were end-to-side anastomosed with abdominal aorta and vena cava inferior of the recipients, heart respectively. The animal model of heterotopic heart transplantation in mice was successfully established. Result Heterotopic heart transplantation in mice was a success in 16 cases and fail in 4 cases with the successful rate being 80?%. Conclusion The murine model of heterotopic heart transplantation can be stably established with simple operation. |
| |
| Keywords: | Heart transplantation Mice Models |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
