Ipragliflozin: A novel sodium-glucose cotransporter 2 inhibitor developed in Japan |
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Authors: | Tsuyoshi Ohkura;Division of Cardiovascular Medicine Endocrinology and Metabolism |
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Institution: | , Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine; |
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Abstract: | Sodium-glucose cotransporter 2 (SGLT2) inhibition induces glucosuria and decreases blood glucose levels in diabetic patients and lowers hypoglycemic risk. SGLT1 is expressed in the kidney and intestine; SGLT1 inhibition causes abdominal symptoms such as diarrhea and reduces incretin secretion. Therefore, SGLT2 selectivity is important. Ipragliflozin is highly selective for SGLT2. In type 2 diabetes mellitus (T2DM), urinary glucose excretion increased to 90 g/24 h after 28 d of treatment with ipragliflozin 300 mg/d. Twelve weeks of ipragliflozin 50 mg/d vs placebo reduced glycated hemoglobin and body weight by 0.65% and 0.66 kg, respectively, in Western T2DM patients, and by 1.3% and 1.89 kg, respectively, in Japanese patients. Ipragliflozin (highly selective SGLT2 inhibitor) improves glycemic control and reduces body weight and lowers hypoglycemic risk and abdominal symptoms. Ipragliflozin can be a novel anti-diabetic and anti-obesity agent. |
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Keywords: | Sodium-glucose cotransporter 2 inhibitor Type 2 diabetes mellitus Ipragliflozin Japan |
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