银杏叶滴丸联用西药治疗不稳定型心绞痛的疗效及对P选择素的影响

目的:探讨银杏叶滴丸联用西药治疗不稳定型心绞痛(UAP)的疗效及对P选择素的影响.方法:94例UAP患者随机分为观察组和对照组各47例,两组均给予常规治疗,包括硝酸酯类、抗血小板聚集药、β-受体阻滞剂、钙拮抗剂等.观察组在此基础上加用银杏叶滴丸,5粒/次,3次/d,口服,两组疗程均为12周.有心绞痛发作者,临时含服硝酸甘油片0.5 mg.记录每周心绞痛发作次数及硝酸甘油用量、心血瘀阻证评分及检测血清P选择素水平.结果:观察组总有效率为95.74％优于对照组的82.99％ (P ＜0.05)；观察组心血瘀阻证积分低于对照组(P＜0.01),中医证候有效率95.74％优于对照组的80.85％ (P ＜0.05)；观察组平均每周心绞痛发作次数及硝酸甘油用量均明显少于对照组(P＜0.01)；观察组血清P选择素水平低于对照组(P＜0.01).结论:银杏叶滴丸能减少心绞痛发作次数、改善症状、提高临床疗效、并能降低P选择素水平、抑制血小板聚集和炎症反应.

Observation on the Efficacy of Ginkgo Leaf Dripping Pill in Auxiliary Treatment of Unstable Angina Pectoris and the Influence on P-selectin

Objective: To investigate the efficacy of Ginkgo leaf dripping pill in auxiliary treatment of unstable angina pectoris (UAP) and the influence on P-selectin. Method: Ninety-four patients with unstable angina pectoris were randomly divided into observation group and control group (n=47 each). Patients in two groups were both given conventional treatment, including nitrates, anti-platelet drugs, beta blockers, calcium antagonists, and Ginkgo leaf dripping pill (5 tablets at a time, tid orally, for 12 weeks) was used in the observation group. Nitroglycerin tablets of 0.5 mg were used for temporarily sublingual when angina pectoris attacks happened. Frequency of angina pectoris and dosage of nitroglycerin, heart blood stasis syndrome score and serum P-selectin levels were record every week. Result: Total effective rate of the observation group (95.74%) was better than the control group (82.99%) (P<0.05). Heart blood stasis syndrome score of the observation group was lower than that in the control group (P<0.01). The effective rate of Chinese medicine syndrome in the observation group (95.74%) was better than that (80.85%) in the control group ( P<0.05). Frequency of angina pectoris attacks and nitroglycerin consumption of the observation group were significantly lower than those in the control group (P<0.01). Levels of serum P-selectin in the observation group was lower than that in the control group (P<0.01). Conclusion: Ginkgo leaf dripping pill could reduce the frequency of angina pectoris attacks, improve symptoms and clinical curative effect. It can also reduce the level of P-selectin, inhibit the platelet aggregation and inflammation.