组织因子TF在乳腺癌中的表达及其临床意义

目的探讨组织因子TF在乳腺癌组织中的表达及其在临床诊断和评价预后中的意义.方法运用免疫组织化学染色法检测45例原发性乳腺癌组织及其相应正常组织、30例乳腺良性病变组织中TF的表达特点,并结合临床病理资料进行分析.结果(1)45例乳腺癌组织及对照正常组织中,分别有31例和4例TF表达阳性,30例乳腺良性病变组织中4例TF表达阳性(P＜0.001).(2)TF的表达与年龄、是否绝经无关(P＞0.05),与肿瘤大小、淋巴结有无转移、组织学分级呈正相关(P＜0.05).(3)TF的表达与乳腺癌预后指标C-erbB-2,p53,PCNA的表达正相关,与雌激素受体(ER)表达负相关(P＜0.05),与孕激素受体(PR)表达无关(P＞0.05).结论TF在乳腺癌组织中呈阳性表达,参与乳腺癌组织的发生发展过程,可能作为乳腺癌的一个预后因子或与其他预后指标结合共同应用于临床.

Expression of tissue factor in breast carcinoma and its clinical significance

Objective To investigate the correlation between the expression of tissue factor (TF) and the diaguosis and prognosis in breast carcinoma. Methods TF expression was studied with immunohistochemical method in specimens of 45 cases of primary breast carcinoma and normal breast tissue, and 30 cases of benign pathological changes of breast. The related clinical and pathological data were analyzed. Results (1) In 45 breast carcinoma tissue and normal breast tissue, TF was detected in 31 and 4 cases respectively and TF was detected in 4 of 30 breast benign pathological changes. Expression of TF was significantly correlated with occurrence of breast earciuoma( P <0.001). (2) Expression of TF was not related to patients age and menopause or not( P >0.05), but was positively correlated with tumor size, histological grading and lymph node metastases ( P <0.05). (3) Expression of TF was positively correlated with C-erbB-2, p53, PCNA, and it was negatively correlated with the level of estrogen receptor( P <0.05). But there was no relationship between TF and the level of progestogen receptor( P >0.05). Conclusion The high positive expression of TF in breast carcinoma suggest it may play a role in the occurrence and developing process of breast carcinoma, and it can be a valuable marker for estimating the prognosis of breast cancer patients.