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中药对神经胶质细胞作用的研究进展
引用本文:窦攀,王学美. 中药对神经胶质细胞作用的研究进展[J]. 环球中医药, 2009, 2(4): 296-300
作者姓名:窦攀  王学美
作者单位:北京大学第一医院中西医结合研究室,100034;北京大学第一医院中西医结合研究室,100034
基金项目:国家自然科学基金面上项目 
摘    要:从中药提取物、单味中药、中药复方制剂三个方面,综述了中药对神经胶质细胞活性的影响。中药调节神经胶质细胞活性的机制可能包括:(1)抑制iNOS表达,从而抑制NO及其产生的氧自由基的毒性;(2)抑制脑缺血和脑出血急性期星形胶质细胞的过度活化和GFAP的过度表达;(3)上调缺血损伤导致的神经胶质细胞分泌NGF;(4)抑制神经系统的免疫炎症反应等各种途径。

关 键 词:神经胶质细胞  中药  综述

Progress in study of the effect of traditional Chinese medicine on glial cells
DOU Pan,WANG Xue-mei. Progress in study of the effect of traditional Chinese medicine on glial cells[J]. Global Chinese Medicine, 2009, 2(4): 296-300
Authors:DOU Pan  WANG Xue-mei
Affiliation:(Department of Integrated Traditional and Western Medicine, Peking University First Hospital, Beijing 100034, China)
Abstract:This article reviews the effects of traditional Chinese medicine(TCM) on glial cells, including 7 extractives, 1 component, and 7 compounds. TCM may modulate the glial ceils through the following mechanisms : inhibiting expression of iNOS, thereby minishing the toxicity of NO and its oxygen free radicals; inhibiting overactivation of astrocytes and overexpression of GFAP in acute cerebral ischemia and cerebra/hemorrhage; promoting glial ceils' secretion of NGF which can be caused by ischemic injury; inhibiting the nervous system's immune inflammatory response; and so on.
Keywords:Glial cells  Traditional Chinese medicine  Review
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