| 中药对神经胶质细胞作用的研究进展 |
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| 引用本文： | 窦攀,王学美.中药对神经胶质细胞作用的研究进展[J].环球中医药,2009,2(4):296-300. |
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| 作者姓名： | 窦攀 王学美 |
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| 作者单位： | 北京大学第一医院中西医结合研究室,100034 |
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| 基金项目： | 国家自然科学基金面上项目 |
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| 摘 要： | 从中药提取物、单味中药、中药复方制剂三个方面，综述了中药对神经胶质细胞活性的影响。中药调节神经胶质细胞活性的机制可能包括：（1）抑制iNOS表达，从而抑制NO及其产生的氧自由基的毒性；（2）抑制脑缺血和脑出血急性期星形胶质细胞的过度活化和GFAP的过度表达；（3）上调缺血损伤导致的神经胶质细胞分泌NGF；（4）抑制神经系统的免疫炎症反应等各种途径。
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| 关 键 词： | 神经胶质细胞 中药 综述 |
Progress in study of the effect of traditional Chinese medicine on glial cells |
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| DOU Pan,WANG Xue-mei.Progress in study of the effect of traditional Chinese medicine on glial cells[J].Global Chinese Medicine,2009,2(4):296-300. |
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| Authors: | DOU Pan WANG Xue-mei |
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| Institution: | (Department of Integrated Traditional and Western Medicine, Peking University First Hospital, Beijing 100034, China) |
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| Abstract: | This article reviews the effects of traditional Chinese medicine（TCM） on glial cells, including 7 extractives, 1 component, and 7 compounds. TCM may modulate the glial ceils through the following mechanisms ： inhibiting expression of iNOS, thereby minishing the toxicity of NO and its oxygen free radicals; inhibiting overactivation of astrocytes and overexpression of GFAP in acute cerebral ischemia and cerebra/hemorrhage; promoting glial ceils＇ secretion of NGF which can be caused by ischemic injury; inhibiting the nervous system＇s immune inflammatory response; and so on. |
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| Keywords: | Glial cells Traditional Chinese medicine Review |
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