| HPLC法测定拉莫三嗪片的含量 |
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| 引用本文： | 陈司汉,邓俊丰,江晓玲.HPLC法测定拉莫三嗪片的含量[J].北方药学,2014,0(7):2-3. |
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| 作者姓名： | 陈司汉 邓俊丰 江晓玲 |
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| 作者单位： | 乐山职业技术学院 乐山 614000;中国医药集团四川抗菌素工业研究所 成都610052;成都医路康医学技术服务有限公司 成都 610041 |
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| 摘 要： | 目的：建立以高效液相色谱法测定拉莫三嗪片含量的方法。方法：色谱柱为Welch Ultusil^TM C18（250×4．6m，5μm）；流动相为甲醇-0．5％三乙胺溶液（用磷酸调解pH值至4．0）（36：64）；流速为0．8ml·min^-1；检测波长265nm；柱温为40℃，进样量为20μl。结果：拉莫三嗪在0．016-0．061mg·ml^-1范围内与峰面积呈良好的线性关系，r=0．9997，加样回收率为98．2％～101．0％。结论：该方法准确、可靠、重复性好，可作为拉莫三嗪片的含量测定方法。
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| 关 键 词： | HPLC 拉莫三嗪 含量测定 |
Determination of Lamotrigine tablets by HPLC |
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| Abstract: | Objective：To establish the HPLC method for the determination of Lamotrigine tablet content. Methods： The analysis was carried on a columu of Welch Ultusil^TM C18 （250×4.6m,5μm）whth a mobile phase of methanol-0,5% triethylamine solution（phosphoric acid R adjust pH value to 4.0）（36：64）at the flow rate of 0.8ml·min^-1.The detection wavelength was 265um. Results： The linearity was obtained over the range of 0.016-0.061mg· ml^-1 （r=0.9997）. The average recoveries of lamotrigine were all in 98.2%-101.0%, and the RSDs were 0.9%.Conclusion：The method is simple,accurate and rapid.It may be suitable for the usual quality control of Lamotrigine tablets. |
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| Keywords: | HPLC Lamotrigine Contents |
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