Trends in Kaposi's sarcoma‐associated Herpesvirus antibodies prior to the development of HIV‐associated Kaposi's sarcoma: A nested case‐control study |
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| Authors: | Katie Wakeham W. Thomas Johnston Angela Nalwoga Emily L. Webb Billy N. Mayanja Wendell Miley Alison M. Elliott Robert Newton |
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| Affiliation: | 1. Medical Research Council/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda;2. Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, Heslington, York, United Kingdom;3. Institute of Cancer Research, University of Glasgow, Scotland, United Kingdom;4. Department of Infectious Disease Epidemiology (ELW), London School of Hygiene and Tropical Medicine, Bloomsbury, London, United Kingdom;5. Department of Clinical Research (AME), London School of Hygiene and Tropical Medicine, Bloomsbury, London, United Kingdom;6. Viral Oncology Section, AIDS and Cancer Virus Program, Leidos Biomedical, Frederick National Laboratory for Cancer Research, Frederick, MD |
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| Abstract: | HIV‐associated Kaposi's sarcoma (KS) is a public health challenge in sub‐Saharan Africa since both the causative agent, Kaposi's sarcoma associated‐herpesvirus (KSHV), and the major risk factor, HIV, are prevalent. In a nested case‐control study within a long‐standing clinical cohort in rural Uganda, we used stored sera to examine the evolution of antibody titres against the KSHV antigens K8.1 and latency‐associated nuclear antigen (LANA) among 30 HIV‐infected subjects who subsequently developed HIV‐related KS (cases) and among 108 matched HIV/KSHV coinfected controls who did not develop KS. Throughout the 6 years prior to diagnosis, antibody titres to K8.1 and LANA were significantly higher among cases than controls (p < 0.0001), and titres increased prior to diagnosis in the cases. K8.1 titres differed more between KS cases and controls, compared to LANA titres. These differences in titre between cases and controls suggest a role for lytic viral replication in the pathogenesis of HIV‐related KS in this setting. |
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| Keywords: | HIV‐associated Kaposi's sarcoma sub‐Saharan Africa Kaposi's sarcoma associated‐herpesvirus HIV AIDS |
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