冠心病患者中血管内皮细胞钙黏蛋白的检测及临床意义

目的 探讨血清血管内皮细胞钙黏蛋白（VE-cadherin）与冠心病病情及与冠状动脉病变程度的关系。方法 经冠状动脉造影（CAG）确诊的冠心病患者61例，其中急性心肌梗死（AMI）20例，不稳定型心绞痛病人（UAP）22例；稳定型心绞痛病人（SAP）19例；另设经CAC排除冠心痛患者19例作为正常对照组。运用酶联免疫吸附法测定各组血清VE-cadherin浓度，对冠心病患者的冠状动脉损害程度行Gensini评分，并与VE-cadherin水平进行直线相关分析。结果 AMI组、UAP组与SAP组中血清VE-cadherin水平均比正常对照组高。差异均有统计学意义（P〈0．05）；AMI组、UAP组与SAP组之间血清VE-cadherin差异均无统计学意义（P〉0．05）；血清可溶性VE-cadherin水平与冠状动脉Gensini评分呈正相关（r=0．43，P〈0．05）。结论 冠心病患者中血清VE-cadhefin浓度与动脉粥样硬化狭窄程度相关，而与冠状动脉斑块的稳定性无明显相关性。

Significance of soluble vascular endothelial cadherin in patients with coronary artery disease

Objective] To investigate the relationship between serum soluble VE-cadherin levels and coronary artery disease. Methods] The levels of serum VE-cadherin were determined by enzyme-1inked immunosorbent assay in 20 acute myocardial infarcation (AMl) cases, 22 unstable angina (UA) cases, 19 stable angina (SA) cases and 19 healthy cases as control. The correlation between the plasma VE-cadherin concentration and the Gensini score was also determined as an index of the severity of coronary atherosclerosis. Results] The plasma concentrations of VE-cadherin (ng/mL) in patients with AMI, UAP, and SAP were higher than in the control subjects(P <0.05), and were similar in the 3 groups with coronary artery disease (P >0.05). The plasma VE-cadherin concentration correlated with the Gensini score(r=0.43, P <0.05). Conclusion] Increased secretion of VE-cadherin from the epicardial arteries is associated with the degree of coronary atherosclerosis, indicating the presence of atherosclerosis rather than disease activity.