子午流注法治疗慢性阻塞性肺疾病加重期痰浊阻肺证疗效研究

目的:观察子午流注法对慢性阻塞性肺疾病(COPD)加重期痰浊阻肺证的影响。方法:选取122例COPD加重期痰浊阻肺证患者随机分为两组。对照组给予基础对症治疗及肠内营养补充,观察组在其基础上联合子午流注法进行治疗。比较两组中医证候积分变化,评估其短期内临床疗效,及血气指标、炎症因子水平及肺功能参数变化。结果:治疗14 d后,两组主症咳嗽、咳痰、喘息、哮鸣、气短及次症鼻塞、口干的中医证候评分、炎症因子及PaCO₂较治疗前均降低(P<0.05),且观察组低于对照组(P<0.05)。经治疗,观察组临床治疗总有效率为91.80%,显著高于对照组的78.69%(P<0.05)。治疗14 d后,两组患者PaO₂、SaO₂较治疗前均上升(P<0.05),且观察组明显高于对照组(P<0.05)。治疗3个月后,两组FEV₁/FVC、MVV、IC与治疗前比较,无统计学差异(P>0.05),且组间比较无统计学意义(P>0.05)。结论:在常规治疗的基础上联合子午流注法择时穴位进针、按摩、耳穴贴压等,可有效改善COPD患者临床症状,提高临床疗效,利于炎症因子水平的降低及血气指标的恢复。

Curative effect of midnight-noon ebb-flow method on chronic obstructive pulmonary disease exacerbation with syndrome of Tanzhuo Zufei

Objective:To observe the effects of midnight-noon ebb-flow method on exacerbation of chronic obstructive pulmonary disease(COPD)with syndrome of Tanzhuo Zufei.Methods:122 patients with COPD exacerbation with syndrome of Tanzhuo Zufei were divided into two group,according to the random number table method.The control group were given routine treatment,and the observation group were combined with midnight-noon ebb-flow method on the basis of the control group.The changes of TCM syndromes scores were compared between the two groups.The short-term clinical efficacy,blood gas index,inflammatory factors levels and lung function parameters were compared.Results:After 14 days of treatment,the scores of TCM symptoms of main symptoms of cough,sputum,whoop,wheezing,shortness of breath,secondary symptoms of nasal congestion and dry mouth,inflammatory factors and PaCO₂ were significantly decreased compared with before treatment(P<0.05),and the scores and levels were significantly lower in the observation group than those in the control group(P<0.05).After treatment,the total effective rate of clinical treatment in the observation group 91.80% was obviously higher than that in the control group 78.69%(P<0.05).After 14 d of treatment,the PaO₂ and SaO₂ in the two groups were significantly increased compared with those before treatment(P<0.05),and the indexes were distinctly higher in the observation group than those in the control group(P<0.05).After 3 months of treatment,there were no statistically significant differences in the FEV₁/FVC,MVV and IC in the two groups compared with those before treatment(P>0.05),and there were no statistically significant differences in the indexes after treatment between the two groups(P>0.05).Conclusion:On the basis of conventional treatment,combining with point acupuncture,massage and auricular acupoint pressing at midnight-noon ebb-flow method can effectively improve the clinical symptoms of COPD patients,enhance the clinical efficacy,and help the reduction of inflammatory factors and recovery of blood gas index.