隔物灸联合阿瑞匹坦及昂丹司琼对晚期肺癌含顺铂方案化疗所致恶心呕吐的预防效果研究

目的:探讨隔物灸联合阿瑞匹坦、昂丹司琼预防晚期肺癌患者顺铂化疗胃肠道毒副反应的临床效果。方法:对80例晚期肺癌化疗患者临床资料进行回顾性分析,单纯服用阿瑞匹坦及昂丹司琼者纳入对照组(n=46),在其基础上联合采取隔物灸治疗者纳入观察组(n=34)。比较化疗第1周期(T₁)、化疗第2周期(T₂)、化疗第3周期(T₃)、化疗第4周期(T₄)结束时,两组患者中医症状积分(嗳气反酸、饮食减少、疲乏无力)变化,分析化疗4周期内,两组患者恶心呕吐及非化疗药物不良反应发生情况。结果:T₁结束时,两组各项中医症状积分比较,差异无统计学意义(P>0.05)。T₂、T₃、T₄结束时,观察组嗳气反酸、饮食减少、疲乏无力中医症状积分与T₁结束时比较,差异无统计学意义(P>0.05),但明显低于同一时间对照组(P<0.05)。化疗4周期内,观察组发生恶心呕吐严重程度明显较对照组更轻,中重度率显著低于对照组(P<0.05); 两组肝功能损害、腹胀/便秘、皮疹、呃逆、眩晕/嗜睡等非化疗药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论:隔物灸联合阿瑞匹坦及昂丹司琼能有效减轻晚期肺癌患者在顺铂化疗方案中出现的恶心呕吐症状,药物安全性良好且不易于产生耐药性,对改善其预后生存质量有利。

Effects of substance-partitioned moxibustion combined with aprepitant and ondansetron in preventing nausea and vomiting induced by chemotherapy with cisplatin for advanced lung cancer

Objective:To explore the clinical effects of substance-partitioned moxibustion combined with aprepitant and ondansetron in preventing gastrointestinal toxicity of cisplatin chemotherapy in patients with advanced lung cancer.Methods:Clinical data of 80 patients with advanced lung cancer chemotherapy were retrospectively analyzed.Patients taking aprepitant and ondansetron alone were included in control group(n=46),and those who were combined with substance-partitioned moxibustion on this basis were included in observation group(n=34).TCM symptoms scores(belching and sour regurgitation,diet reduction,lassitude)were compared between the two groups on the 1st cycle(T₁),2nd cycle(T₂),3rd cycle(T₃)and 4th cycle(T₄)of chemotherapy.Occurrence of nausea and vomiting and non-chemotherapeutic adverse reactions were analyzed in the two groups during 4 cycles of chemotherapy.Results:At the end of T₁,there were no significant differences in TCM symptoms scores between the two groups(P>0.05).At the end of T₂,T₃ and T₄,there were no significant differences in TCM symptoms scores of belching and sour regurgitation,diet reduction and lassitude in observation group compared with those at the end of T₁(P>0.05),but were significantly lower than those in control group at the same time(P<0.05).Within 4 cycles of chemotherapy,severity of nausea and vomiting in observation group was obviously lighter than that in control group,and the moderate-to-severe rate was significantly lower than that in control group(P<0.05).There were no significant differences in incidence rates of non-chemotherapeutic adverse reactions of liver function damage,bloating/constipation,rash,hiccup and dizziness/lethargy between the two groups(P>0.05).Conclusion:Substance-partitioned moxibustion combined with aprepitant and ondansetron can effectively alleviate symptoms of nausea and vomiting in cisplatin chemotherapy of patients with advanced lung cancer.And it has good drug safety,and is not easy to produce drug resistance,thus improving the prognosis and quality of life.