天然麝香抗炎有效成分的研究

天然麝香是雄性麝(Moschus mosohiferus L)的腺分泌物干燥粉末,有强烈香气,是珍贵药材。医学研究证明,麝香对中枢神经与心脏具有一定作用,并能降压,加强儿茶酚胺对β-受体的兴奋作用还具有雄激素样作用及显著的抗炎作用。 天然麝香的化学成分,过去重点研究了其亲脂性部分,但对水溶性成分缺乏研究。我们发现麝香水溶性部分有明显的抗炎活性,并从中分出一个主要抗炎有效成分-麝香抗炎

STUDIES ON THE ANTIINFIAMMATORY PRINCIPLE OF MUSK

The water soluble components of Musk were investigated by chromatographic and ion-exchange methods. A peptide, named Antiinflammatory principle I with antiinflammtory action more than twenty times that of hydrocortisone, was isolated. The molecular weight of Antiinflammatory principle I was estimated to be about five to six thousand by molecular sieve on sephadex G-75 column. Antiinflammry principle I was shown to consist of about 15 amino acids by the amino acid automatic analyzer.