舌鳞癌环氧化酶-2的表达及临床意义

目的探讨环氧化酶-2(COX-2)的表达与舌鳞癌生物学行为的关系及意义.方法采用免疫组化S-P法检测10例正常口腔黏膜、10例口腔黏膜炎症组织和37例舌鳞癌中COX-2的表达,并结合临床病理资料进行分析.结果舌鳞癌中COX-2的表达明显高于正常舌黏膜和炎症组织(P《0.01).COX-2的表达与舌鳞癌的大小、临床分期及淋巴结转移无明显相关,但与病理分级相关性显著,随分化程度的降低而增强(P=0.003).结论 COX-2很可能在舌癌的发生、发展中起重要作用,抑制COX-2的活性有望成为舌癌防治的新途径.

Expression and clinic significance of cyclooxygenase-2 in tongue squamous cell carcinoma

Objective To reveal the relations between expression of cyclooxygenase-2(COX-2) and tumor biological behavior and implications in tongue squamous cell carcinoma(TSCC). Methods With immunohistochemistry (S-P) method ,the expression of COX-2 was detected in 37 cases of tongue squamous cell carcinoma,10 cases of tongue normal mucosa and 10 cases of tongue inflammation,then analysised with clinical and pathological data. Results Compared to tongue normal mucosa and tongue inflammation, the expression of COX-2 was significantly higher in TSCC(P<0.01). The expression of COX-2 in TSCC had no relation with tumor size, clinical state or lymph node metastasis. But the expression in cases with poor differentiation was significantly higher than in those with well differentiation(P=0.003).Conclusion The results indicate that COX-2 may play an important role in the occurrence and development of TSCC. Inhibiting activity of COX-2 may be a new way in prevention and treatment of TSCC.