Liver-directed therapies for patients with primary liver cancer and hepatic metastases |
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Authors: | Cletus A Arciero MD Elin R Sigurdson MD PhD |
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Institution: | (1) Department of Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, 19111 Philadelphia, PA, USA |
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Abstract: | Opinion statement Liver cancer, whether primary or metastatic, is a major cause of death throughout the world. The surgical management of these
diseases varies according to the extent of disease and the overall health of the patient. Surgical resection of hepatic disease
remains the only chance for cure. However, a large proportion of patients with liver cancer are unable to undergo a complete
surgical resection. These patients are often treated with liver-directed therapies. Although not as effective as surgical
resection, these approaches can help to improve the survival of patients. In patients with primary liver cancer, underlying
liver disease often prohibits surgical intervention. However, survival advantages have been gained with the application of
percutaneous alcohol injection and radiofrequency ablation (RFA). In patients with hepatic metastases, the number of metastases
is often what prevents surgical resection. In these patients, RFA, cryoablation, and hepatic artery infusional therapy have
all aided in prolonging survival. As chemotherapeutic agents improve and targeted therapies are developed, more patients will
be able to undergo surgical management of their liver cancer, primary or metastatic. |
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