Kinetics of rate controlled rectally administered ranitidine to male volunteers |
| |
Authors: | H de Bree and A C de Boer |
| |
Institution: | (1) Division of Pharmacology, Center for Bio-Pharmaceutical Sciences, State University of Leiden, P.O. Box 9503, 2300 RA Leiden, The Netherlands;(2) Present address: Analytical Department, Duphar Research Laboratories, C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands |
| |
Abstract: | Ranitidine hydrochloride solution was given rectally to six healthy volunteers by means of an osmotic pump (Osmet®) at a zero-order rate for 8 h. Quite constant steady-state drug concentrations were achieved in the range of 64–123 ng/ml plasma (meanC
ss: 100.6 ng/ml). The mean absorption time was 0.45 h (range 0–1.02 h), indicating that absorption was not always instantaneous. It is concluded that the Osmet® system together with the rectal route offer the possibility for achieving steady-state concentrations of ranitidine, enabling the determination of pharmacodynamic effects. In addition, the rectal route can be considered as an alternative to oral and intravenous administration. |
| |
Keywords: | Administration rectal Osmotic pump Pharmacokinetics Ranitidine |
本文献已被 SpringerLink 等数据库收录! |
|