| 慢性阻塞性肺疾病急性发作期痰及血清白介素-8的测定及意义 |
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| 引用本文： | 钟小宁,柳广南,陆光润,邓静敏,李超乾.慢性阻塞性肺疾病急性发作期痰及血清白介素-8的测定及意义[J].广西医科大学学报,1999,16(3):275-276. |
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| 作者姓名： | 钟小宁 柳广南 陆光润 邓静敏 李超乾 |
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| 作者单位： | 广西医科大学第一附属医院呼吸内科,南宁,530021 |
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| 摘 要： | 目的 探讨白介素－８（ＩＬ－８）在慢性阻塞性肺疾病（ＣＯＰＤ）气道炎症中的作用。方法 采用酶不联免疫吸附法（ＥＬＩＳＡ）检测１０例ＣＯＰＤ急性发作期和１０例正常对照组及血清的ＩＬ－８水平。结果 ＣＯＰＤ患者痰ＩＬ－８水平为（１９８２．２４±９０１．０７）ｎｇ／Ｌ、血清ＩＬ－８水平为（６６８．１６±３９８．０５）ｎｇ／Ｌ，明显高于正常人痰（７６９．６±５７０．１４）ｎｇ／Ｌ及血清（１１７．７８±１２
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| 关 键 词： | 阻塞性 肺疾病 气道炎症 白介素-8 |
| 修稿时间： | 1998-09-30 |
DETECTION AND SIGNIFICANCE OF INTERLEUKIN-8 IN INDUCED SPUTUM AND SERUM FROM ACUTE CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
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| Zhong Xiaoning,Liu Guangnan,Lu Guangrun,et al.DETECTION AND SIGNIFICANCE OF INTERLEUKIN-8 IN INDUCED SPUTUM AND SERUM FROM ACUTE CHRONIC OBSTRUCTIVE PULMONARY DISEASE[J].Journal of Guangxi Medical University,1999,16(3):275-276. |
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| Authors: | Zhong Xiaoning Liu Guangnan Lu Guangrun |
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| Abstract: | Objective: To explore the role of interleukin8(IL8) in the airway inflammation of chronic obstructive pulmonary disease (COPD) Method: IL8 of induced sputum and serum in 10 patients with acute COPD and in 10 normal subjects was detected by ELISA method Results: IL8 of induced sputum (19822490107)ng/L and serum (6681639805)ng/L in patients with cute COPD was much higher than that of induced sputum(769657014)ng/L and serum (1177812361)ng/L in normal subjects (P<001 and P<005)IL8 of induced sputum was also much higher than that of serum in COPD (P<001)And there was no correlation between IL8 of induced sputum and that of serum in patients with COPD (r=018,P>005)In addition,there was high negative correlation between IL8 of induced sputum and FEV1 in patients with COPD (r=-067,P<001) Conclusion: IL8 play an important role in the airway inflammation and airway obstruction of COPDDetection of the level of IL8 in induced sputum was more capable of reflecting airway inflammation of COPD than in serum\= |
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| Keywords: | obstructive pulmonary disease airway inflammation interleukin8\=\= |
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