| 乳腺肿瘤细胞核DNA含量分析 |
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| 引用本文： | 郑唯强 左连富. 乳腺肿瘤细胞核DNA含量分析[J]. 第二军医大学学报, 1993, 14(3): 238-241 |
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| 作者姓名： | 郑唯强 左连富 |
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| 作者单位： | 第二军医大学病理解剖学教研室 200433(郑唯强，詹镕洲)，河北省肿瘤研究所 050011(左连富)，河北省肿瘤研究所 050011(郭建文) |
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| 摘 要： |
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| 关 键 词： | 乳腺癌 DNA 流式细胞术 |
Analysis of Nuclear DNA Content in Breast Tumours |
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| Zheng Weiqiang,Zhan Rongzhou,Zuo Lianfu,Guo Jianwen. Analysis of Nuclear DNA Content in Breast Tumours[J]. Former Academic Journal of Second Military Medical University, 1993, 14(3): 238-241 |
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| Authors: | Zheng Weiqiang Zhan Rongzhou Zuo Lianfu Guo Jianwen |
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| Abstract: | Nuclear DNA content in 103 cases of malignant and benign breast tumours were determined by means of flow cytometry. It was found that DNA in all the benign lesions showed diploids. In contrast, only 32.3 percent of the cancers had diploids, while 62.3% had additional DNA aneuploids including near-diploids (18.4%); triploids (22.3%); and tetraploids (8.2%) etc. Both the cellular proportion in S-phase and DNA index were significantly higher in malignant breast tumours than those in benign ones (P<0.01). Besides, there was no relationship between DNA content and age of the patients, size of the primary tumours, and nodal involvement (P>0.05). The results indicate that the analysis of DNA content is a useful and objective adjunct in the assessment of proliferative activity and biological behavior on breast tumour. |
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| Keywords: | breast neoplasms DNA flow cytometry pathology human female |
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