| 三七总皂甙对实验性脑缺血脑血流及血脑屏障的影响作用 |
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| 引用本文： | 刘建辉,冀凤云,王婷,解旭东,姚斌.三七总皂甙对实验性脑缺血脑血流及血脑屏障的影响作用[J].河北医药,2002,24(4):249-250. |
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| 作者姓名： | 刘建辉 冀凤云 王婷 解旭东 姚斌 |
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| 作者单位： | 071000,河北省保定市,解放军252医院神经内科 |
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| 摘 要： | 目的 观察三七总皂甙对脑缺血后再灌流期间血脑屏障及脑血流的影响。方法 利用大鼠局灶性脑缺血再灌流和全脑缺血再灌流损伤两种实验模型。结果 与相应对照组比较，不论是全脑缺血还是局灶性脑缺血1h后再灌注3d，应用三七总皂甙的各组动物及水肿明显减轻，血脑屏障通透性改善，大脑局部血流量显著增加。结论 三七总皂甙对脑缺血后脑水肿、血脑屏障、大脑局部血流量具有保护作用。
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| 关 键 词： | 脑缺血 再灌注损伤 血脑屏障 脑血流 三七总皂甙 实验研究 |
| 修稿时间： | 2001年10月10 |
The effects of notoginsenoside on blood-brain barrier and cerebral blood flow during reperfusion of cerebral ischemia in rats |
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| LIU Jianhui,JI Fengyun,WANG Ting,et al..The effects of notoginsenoside on blood-brain barrier and cerebral blood flow during reperfusion of cerebral ischemia in rats[J].Hebei Medical Journal,2002,24(4):249-250. |
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| Authors: | LIU Jianhui JI Fengyun WANG Ting |
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| Institution: | LIU Jianhui,JI Fengyun,WANG Ting,et al.Department of Neurology,The 252nd Hospital of PLA,Baoding 071000 |
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| Abstract: | Objective To observe the effects of notoginsenoside on blood brain barrier and cerebral blood flow during reperfusion in rats.Methods The models of local cerebral ischemia and global ischemia were used in rats.Results Both brain water content and Evans blue extravasation decreased,and cerebral blood flow increased significantly in notoginsenoside groups on the third day of reperfusion after 1 hour of cerebral ischemia induced by 4 vessel occlusion and by middle artery occlusion.Conclusion Notoginsenoside is of benefit to encephal edema,blood brain barrier and cerebral blood flow after cerebral ischemia. |
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| Keywords: | cerebral ischemia reperfusion injury blood brain barrier cerebral blood flow notoginsenoside |
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