口腔癌前损害与鳞癌患者口腔白色念珠菌分离株的磷脂酶活性研究

目的:研究口腔粘膜癌前损害和口腔鳞癌患者以及正常人的口腔白色念珠菌分离株的磷脂酶活性。方法: 应用蛋黄培养基沉淀环面积测量法,研究来自于口腔粘膜癌前损害(21株)、口腔鳞癌(15株)患者以及正常人(19 株)共55株白色念珠菌的磷脂酶活性大小。结果:虽然口腔癌前损害组的沉淀环面积平均值较正常对照组为高, 但却无统计学差异;而口腔鳞癌组白色念珠菌的值较口腔癌前损害及正常对照组均小(P<0105),说明口腔鳞癌组分离株的磷脂酶活性较口腔癌前损害组及正常对照组高。结论:在口腔癌前损害和鳞癌患者口腔中的白色念珠菌分离株具有不同的毒力学特点,提示白色念珠菌在这两种具有关联性的疾病中所起的作用可能具有差异。

Phospholipase Activities of Candida albicans Isolates from Oral Pre-malignant Lesions and Oral Cancers

Objective:The aim of this study is to compare activities of phospholipase of Candida albicans isolates from oral cavities of two groups of patients, including oral pre_malignant lesions and oral cancers. Methods:A total of 55 isolates, including oral pre_malignant lesions (21), oral cancers (15), and normal health control (19), were studied using the precipitate zone assay on the egg yolk agar.Results:No significant difference was found in phospholipase activities between these isolates from normal controls and oral pre_malignant lesions, while the activities of phospholipase of isolates from oral cancers were higher than those of the normal controls.Conclusion:Candida albicans may play different roles in different manners in these two closely related diseases.