| 5-氟尿嘧啶、阿霉素诱导肝内胆管癌细胞凋亡和bcl-2基因表达研究 |
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| 引用本文： | 夏光涛,王玲,张尚忠,孙红梅. 5-氟尿嘧啶、阿霉素诱导肝内胆管癌细胞凋亡和bcl-2基因表达研究[J]. 山东医药, 2003, 43(32): 8-9 |
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| 作者姓名： | 夏光涛 王玲 张尚忠 孙红梅 |
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| 作者单位： | 1. 山东大学齐鲁医院,山东济南,250012
2. 曲阜市人民医院 |
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| 摘 要： | 目的研究5-氟尿嘧啶(5-FU)及阿霉素诱导肝内胆管癌细胞9810凋亡情况，并对其机制作初步探讨。方法应用流式细胞仪检测肝内胆管癌细胞凋亡的情况，并检测bcl-2基因表达情况。结果随着两种药物浓度的增加，细胞凋亡率逐步上升，bcl-2基因表达下调，两种药物小剂量联合作用效果优于一种药物大剂量应用。结论5-FU及阿霉素能诱导肝内胆管癌细胞凋亡，bcl-2基因表达下调是其作用的一种机制。
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| 关 键 词： | 肝内胆管癌 bcl-2基因 癌细胞凋亡 阿霉素 表达 诱导 5-氟尿嘧啶 下调 机制 增加 |
| 修稿时间： | 2003-08-12 |
Fliorouracil or adriacin indncing the apoptosis of intrahepatic cholangiocarcinoma cell and influencing expression of bcl-2 gene |
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| Xia Guangtao,Wang Ling,Zhang Shangzhong,et al. Fliorouracil or adriacin indncing the apoptosis of intrahepatic cholangiocarcinoma cell and influencing expression of bcl-2 gene[J]. Shandong Medical Journal, 2003, 43(32): 8-9 |
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| Authors: | Xia Guangtao Wang Ling Zhang Shangzhong et al |
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| Abstract: | Objective To invest the apoptosis of intrahepatic cholangiocarcinoma cell and expression of bcl-2 gene induced by fliorouracil and adriacin .Methods We applicated annisoconcentration of fliorouracil and adriacin to dispose cancer cell and detected its apoptosis and expression of bcl-2 gene by flow cytometer.Results We found that apoptosis of intrahepatic cholangiocarcinoma was up step by step flowing two drug's concentration, expression of bcl-2 gene was down.Conclusions Fliorouracil or adriacin could induce the apoptosis of intrahepatic cholangiocarcinoma cell and influencing expression of bcl-2 gene may be a reason of it. |
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| Keywords: | Intrahepatic cholangiocarcinoma Fliorouracil Adriacin Apoptosis bcl-2$$$$ |
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