十二指肠溃疡愈合过程中上皮的变化

应用锡类散和甲氰咪胍治疗了25例经内窥镜确诊的活动性十二指肠球溃疡患者。分别在疗前及疗后3周取溃疡旁活检组织进行HE、AB(pH2.5)、PAS和AB(pH2.5)-PAS染色。根据形态学特点,将其分为肠型、胃型及过渡型上皮。并测量游离腔面细胞密度及长度百分比。结果:溃疡愈合早期(3周),杯状细胞的恢复主要出现在溃疡旁上皮;可见到较多移行上皮。两组形态学变化无明显差异。根据内窥镜观察,溃疡愈合后仍有胃型粘膜及移行上皮存在。在大多数肠绒毛还可发现胃化生粘膜。并对上述机制进行了探讨。

THE CHANGE IN EPITHELIUM OF DUODENAL ULCER DURING HEALING PROCESS

25 patients with endoscopy confirmed active duodenal ulcer were treated with Xi Lei San or ci-metidine. Biopsy specimens were taken before and 3 weeks after treatment. Specimens were stained separately with HE, AB (pH2.5), PAS, and AB(pH2.5)/PAS. According to the morphological characteristics, the epithelium was divided into intestinal, gastric and transitional types. The percentage of the length and density of cells of all types were measured. The results were obtained as follows: during early phase of healing (3 weeks), goblet cells recovered most markedly in the epithelium close to the lesion. Transitional epithelium could relatively easily be observed.The Xi Lei San and cimetidine produced similar morphological changes. Endoscopically, even after the ulcer was healed, gastric and transitional epithelial cells could still be seen. Hypoplasia was observed in most of epithelial villi.