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| 候选基因单核苷酸多态性与胃癌患者卡培他滨联合紫杉醇化疗后生存期的关系 | |
| 引用本文： | 郑磊贞,顾建春,龚继芳,李小平,陈思宇,章莉,焦晓栋,王杰军.候选基因单核苷酸多态性与胃癌患者卡培他滨联合紫杉醇化疗后生存期的关系[J].上海交通大学学报(医学版),2011,31(5):598-603. |
| 作者姓名： | 郑磊贞 顾建春 龚继芳 李小平 陈思宇 章莉 焦晓栋 王杰军 |
| 作者单位： | 1. 上海交通大学医学院附属新华医院肿瘤科,上海,200092 2. 北京肿瘤医院消化内科,北京,100142 3. 第二军医大学附属长征医院肿瘤科,上海,200003 |
| 基金项目： | 上海市卫生局基金(2008135)~~ |
| 摘 要： | 目的探讨热点候选肿瘤相关基因的单核苷酸多态性(SNPs)与胃癌患者卡培他滨联合紫杉醇化疗后生存期的关系。方法收集93例经病理学检查确诊的胃癌患者,采用卡培他滨联合紫杉醇为主的方案进行化疗。用TaqMan-MGB探针进行原癌基因TP53 rs1042522(G/C)、代谢相关基因GSTP1 rs1695(A/G)和CYP11B2 rs1799998(T/C)以及DNA损伤修复相关基因XRCC1 rs1799782(C/T)和ERCC2 rs1799793(G/A)的基因分型。比较不同基因型患者化疗后中位生存时间(MST)及各种因素对预后的影响。结果对93例患者的中位随访时间为29.6个月,MST为34.93个月。TP53 rs1042522(G/C)多态性位点与胃癌患者化疗后的MST相关,携带TP53 rs1042522野生基因型G/G组的MST为51.2个月,而携带变异基因型(G/C+C/C)组的MST为26.6个月,经log-rank检验两组间差异无统计学差异,但较为接近(P=0.073);其他基因多态性与MST无显著相关性(P>0.05)。Cox回归分析显示性别、手术和病理分期是影响胃癌患者化疗预后效果的... |
| 关 键 词： | 胃癌 DNA修复基因 单核苷酸多态性 卡培他滨 紫杉醇 |
Relationship between single nucleotide polymorphisms of candidate genes and survival of patients with gastric cancer undergoing chemotherapy with capecitabine and paclitaxel |
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| ZHENG Lei-zhen,GU Jian-chun,GONG Ji-fang,LI Xiao-ping,CHEN Si-yu,ZHANG Li,JIAO Xiao-dong,WANG Jie-jun.Relationship between single nucleotide polymorphisms of candidate genes and survival of patients with gastric cancer undergoing chemotherapy with capecitabine and paclitaxel[J].Journal of Shanghai Jiaotong University:Medical Science,2011,31(5):598-603. | |
| Authors: | ZHENG Lei-zhen GU Jian-chun GONG Ji-fang LI Xiao-ping CHEN Si-yu ZHANG Li JIAO Xiao-dong WANG Jie-jun |
| Institution: | ZHENG Lei-zhen1,GU Jian-chun1,GONG Ji-fang3,LI Xiao-ping1,CHEN Si-yu1,ZHANG Li1,JIAO Xiao-dong2,WANG Jie-jun2(1.Department of Oncology,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai200092,China,2.Department of Oncology,Changzheng Hospital,The Second Military Medical University,Shanghai200003,3.Department of Digestive Diseases,Beijing Cancer Hospital,Beijing100142,China) |
| Abstract: | Objective To investigate the relationship between single nucleotide polymorphisms of tumor-associated candidate genes and survival of patients with gastric cancer undergoing chemotherapy with capecitabine and paclitaxel.Methods Ninety-three patients pathologically confirmed of gastric cancer were selected,and received chemotherapy with capecitabine and paclitaxel.Genotypes of protooncogene TP53rs1042522(G/C),metabolism-associated gene GSTP1rs1695(A/G) and CYP11B2rs1799998(T/C),DNA repair-associated gene XRC... |
| Keywords: | gastric cancer DNA repair gene single nucleotide polymorphism capecitabine paclitaxel |
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