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| 甲磺酸罗哌卡因和盐酸罗哌卡因硬膜外阻滞的药代动力学特征比较 | |
| 引用本文： | 蔡美华,张马忠,荣征星,江涛,王玉梅,崔永耀.甲磺酸罗哌卡因和盐酸罗哌卡因硬膜外阻滞的药代动力学特征比较[J].上海交通大学学报(医学版),2011,31(5):584-587. |
| 作者姓名： | 蔡美华 张马忠 荣征星 江涛 王玉梅 崔永耀 |
| 作者单位： | 1. 上海交通大学基础医学院药理学教研室,上海,200025;上海交通大学医学院附属上海儿童医学中心儿科转化医学研究所,上海,200127 2. 上海交通大学医学院附属上海儿童医学中心儿科转化医学研究所,上海,200127 3. 上海交通大学基础医学院药理学教研室,上海,200025 4. 江苏恩华药业股份有限公司临床医学部,江苏,221007 |
| 摘 要： | 目的比较0.894%甲磺酸罗哌卡因和0.75%盐酸罗哌卡因的药代动力学特征。方法 40例择期下腹部、下肢手术病例,随机分为甲磺酸罗哌卡因组(n=20)和盐酸罗哌卡因组(n=20)。于给药前和给药后2、5、10、20、30、45、60、90、120、180、240、300、360、720、1 440 min抽取肘前静脉血,采用反相高效液相色谱紫外法,测定血浆中甲磺酸或盐酸罗哌卡因浓度。采用DAS 2.0软件计算药代动力学参数,并比较两组药代动力学参数的特征。结果甲磺酸罗哌卡因和盐酸罗哌卡因组的表观分布容积(Vd/F)分别为(2.1±0.7)和(2.7±1.1)L/kg,消除半衰期(T1/2β)分别为(333±89)和(378±112)min,药时曲线下总面积(AUC0-∞)分别为(480±168)和(425±126)mg.min/L,清除率(CL/F)分别为(4.6±1.3)和(5.1±1.3)mL/(min.kg),达峰时间(Tpeak)分别为(26±13)和(29±20)min,峰浓度(Cmax)分别为(1 732±833)和(1 345±341)ng/mL,两组药代动力学参数比较差异无统计学意义(P>0.... |
| 关 键 词： | 甲磺酸罗哌卡因 盐酸罗哌卡因 色谱紫外法 反相高效液相 药代动力学 |
Comparision of pharmacokinetics between ropivacaine methanesulfonate and ropivacaine hydrochloride during epidural block |
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| CAI Mei-hua,ZHANG Ma-zhong,RONG Zheng-xing,JIANG Tao,WANG Yu-mei,CUI Yong-yao.Comparision of pharmacokinetics between ropivacaine methanesulfonate and ropivacaine hydrochloride during epidural block[J].Journal of Shanghai Jiaotong University:Medical Science,2011,31(5):584-587. | |
| Authors: | CAI Mei-hua ZHANG Ma-zhong RONG Zheng-xing JIANG Tao WANG Yu-mei CUI Yong-yao |
| Institution: | CAI Mei-hua1,2,ZHANG Ma-zhong2,RONG Zheng-xing1,JIANG Tao1,WANG Yu-mei3,CUI Yong-yao1(1.Department of Pharmacology,Basic Medical College,Shanghai Jiaotong University,Shanghai200025,China,2.Institute for Pediatric Translational Medicine,Shanghai Children's Medical Center,Shanghai Jiaotong University School of Medicine,Shanghai200127,3.Department of Clinical Medicine,Jiangsu Nhwa Pharmaceutical Coporation Limited,Jiangsu221007,China) |
| Abstract: | Objective To compare the pharmacokinetics between 0.894% ropivacaine methanesulfonate and 0.75% ropivacaine hydrochloride. Methods Forty patients undergoing lower abdominal or lower limb surgery were randomly divided into ropivacaine methanesulfonate group(n=20) and ropivacaine hydrochloride group(n=20).Blood samples were collected from an antecubital vein before administration and 2,5,10,20,30,45,60,90,120,180,240,300,360,720 and 1 440 min after administration,and the concentrations of ropivacaine methanes... |
| Keywords: | ropivacaine methanesulfonate ropivacaine hydrochloride ultraviolet reversed phase high performance liquid chromatography pharmacokinetics |
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