| Immunophenotypings of Malignant Epithelial Mesothelioma and Their Roles in the Differential Diagnosis |
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| 引用本文： | 阮秋蓉,胡余昌. Immunophenotypings of Malignant Epithelial Mesothelioma and Their Roles in the Differential Diagnosis[J]. 华中科技大学学报(医学英德文版), 2004, 24(2): 112-115. DOI: 10.1007/BF02885405 |
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| 作者姓名： | 阮秋蓉 胡余昌 |
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| 作者单位： | DepartmentofPathology,SchoolofBasicMedicalSciences,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430030,China |
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| 摘 要： | To investigate the immunophenotypings of malignant epithelial mesothelioma (MEM),and to seek the valuable markers in distinguishing peritoneal MEM from peritoneal metastatic ovari-an adenocarcinoma (OA) and colorectal adenocarcinoma (CA), immunohistochemical SP method was used to detect expressions of HBME-1, E-cadherin, CA19-9, MOC-31 and CK7 in paraffin-embedded tissues of 18 cases of MEM, 20 OA and 20 CA. The results showed that there was a sig-nificant difference in the expressions of E-cadherin, CA19-9 and MOC-31 between MEM and OA group (P＜0.05). Similarly, the difference in the expression of HBME-1, E-cadherin, CA19-9,MOC-31 and CK7 between MEM and CA groups is significant (P＜0.05). These results indicate that HBME-1 could be used as a positive marker in distinguishing MEM from CA. E-cadherin,CA19-9 and MOC-31 are considered to be useful negative markers in diagnostic distinction between MEM and metastatic adenocarcinomas, including OA and CA. CK7 is the best positive marker in distinguishing MEM from CA, but this marker appears to be valueless in discriminating MEM from OA.
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| 关 键 词： | 恶性上皮间皮瘤 肿瘤转移 细胞因子 免疫组织化学 抗原 |
| 收稿时间： | 2003-11-07 |
Immunophenotypings of malignant epithelial mesothelioma and their roles in the differential diagnosis |
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| Ruan Qiurong,Hu Yuchang. Immunophenotypings of malignant epithelial mesothelioma and their roles in the differential diagnosis[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2004, 24(2): 112-115. DOI: 10.1007/BF02885405 |
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| Authors: | Ruan Qiurong Hu Yuchang |
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| Affiliation: | Departnent of Pathology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | To investigate the immunophenotypings of malignant epithelial mesothelioma (MEM), and to seek the valuable markers in distinguishing peritoneal MEM from peritoneal metastatic ovarian adenocarcinoma (OA) and colorectal adenocarcinoma (CA), immunohistochemical SP method was used to detect expressions of HBME-1, E-cadherin, CA19-9, MOC-31 and CK7 in paraffin-embedded tissues of 18 cases of MEM, 20 OA and 20 CA. The results showed that there was a significant difference in the expressions of E-cadherin, CA19-9 and MOC-31 between MEM and OA group (P<0.05). Similarly, the difference in the expression of HBME-1, E-cadherin, CA19-9, MOC-31 and CK7 between MEM and CA groups is significant (P<0.05). These results indicate that HBME-1 could be used as a positive marker in distinguishing MEM from CA. E-cadherin, CA19-9 and MOC-31 are considered to be useful negative markers in diagnostic distinction between MEM and metastatic adenocarcinomas, including OA and CA. CK7 is the best positive marker in distinguishing MEM from CA, but this marker appears to be valueless in discriminating MEM from OA. |
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| Keywords: | malignant mesothelioma metastatic adenocarcinoma immunophenotyping HBME-1 E-cadherin CA19-9 MOC-31 CK7 |
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