| 法舒地尔对急性心肌梗死大鼠炎性细胞因子表达的影响 |
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| 引用本文： | 马建英,谭丽娟,潘娜娜. 法舒地尔对急性心肌梗死大鼠炎性细胞因子表达的影响[J]. 临床心血管病杂志, 2011, 27(4) |
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| 作者姓名： | 马建英 谭丽娟 潘娜娜 |
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| 作者单位： | 青岛大学医学院附属医院心内科,山东青岛,266003 |
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| 摘 要： | 目的:探讨法舒地尔对急性心肌梗死(AMI)大鼠炎性细胞因子表达的影响及细胞因子表达与Rho激酶的关系.方法:选取雄性Wistar大鼠,建立大鼠AMI模型,将术后存活大鼠随机分为治疗组(F组)和AMI组;另设假手术组(S组),只在其左前降支下穿线不结扎.F组给予法舒地尔5 mg/kg,AMI组和S组给予等量0.9%氯化钠溶液,腹腔注射,每日2次.4周后,用Nikon 4多导生理记录仪检测血流动力学指标,放射免疫法测血清中肿瘤坏死因子(TNF)-α和白细胞介素-1β(IL-1β)含量,EvensBlue及NBT双染确定缺血及梗死面积,RT-PCR法测定Rho激酶mRNA的表达.结果:与S组相比,AMI组细胞因子TNF-α和IL-1β、左室舒张末压(LVEDP)表达明显升高,而左室收缩压(LVSP)和左室压力上升/下降最大速率(±dp/dtmax)明显减低(P<0.05).与AMI组比较,F组梗死面积显著减小,TNF-α和IL-1β表达水平明显下降,Rho激酶mRNA表达显著减少;F组更明显地降低LVEDP,升高LVSP和±dp/dtmax(P<0.01),左室功能明显改善.结论:法舒地尔可以降低AMI大鼠炎性细胞因子及心肌Rho激酶表达,保护缺血心肌,减少心肌梗死面积,改善心功能.
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| 关 键 词： | 急性心肌梗死 法舒地尔 炎性细胞因子 Rho激酶 |
Effect of fasudil on the inflammatory cytokine expression in rats after acut myocardial infarction |
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| MA Jianying,TAN Lijuan,PAN Nana. Effect of fasudil on the inflammatory cytokine expression in rats after acut myocardial infarction[J]. Journal of Clinical Cardiology, 2011, 27(4) |
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| Authors: | MA Jianying TAN Lijuan PAN Nana |
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| Affiliation: | MA Jianying TAN Lijuan PAN Nana(Department of Cardiology,the Affiliated Hospital of Medical College,Qingdao University,Qingdao,266003,China) |
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| Abstract: | Objective:To explore the effect of fasudil on the inflammatory cytokine expression in rats heart following acut myocardial infarction(AMI) and its relationship with the Rho kinase.Method:The model of AMI rats were divided into two groups,treated group(F group) and AMI group,besides another group of sham-operation(S group).Fasudil 5 mg/kg were given into the F group twice a day.The AMI and Sgroup were given equivalent normal saline.Nikon 4 multi-channel physiological recorder records hemodynamics parameters.... |
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| Keywords: | acut myocardial infarction fasudil inflammatory cytokine |
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