外科感染铜绿假单胞菌的耐药性分析

目的：探讨基层医院外科感染铜绿假单胞菌（PAE）对常用抗菌药物的耐药性,为临床合理使用抗生素提供实验依据。方法：从外科感染性标本中分离的179株PAE培养鉴定严格按照《全国临床检验操作规程》进行,采用KB法对PAE进行14种常用抗菌药物的药敏试验。结果：PAE对常用抗菌药物的药敏试验结果表明：PAE对碳青霉烯类抗生素亚胺培南和美罗培南敏感率最高,均为97.8%;其次,对头孢哌酮/舒巴坦、哌拉西林/他唑巴坦、阿米卡星等敏感率较高,分别为87.7%、84.4%、80.4%;而对氨曲南、头孢噻肟、环丙沙星、左氧氟沙星耐药率很高,均〉50%。结论：我院外科医院感染铜绿假单胞菌具有多药耐药性,必须加强监测与控制。

Antimicrobial resistance in surgical infection causing by Pseudomonas aeruginosa

Objective：To approach the antimicrobial resistance to commonly used antibiotics in surgical infection causing by Pseudomonas aeruginosa（PAE） in grass-root hospitals and provide the experimental evidence for reasonably clinical choice of antibiotics.Method：Referring to National Guide to Clinical Laboratory Operation Procedure,179 isolates of PAE isolated from surgically infective specimen in our hospital were cultured and identified.In vitro,14 antibiotics＇ susceptibility testings were performed by K-B methods.Result：The susceptibility testing results indicated that sensitivity rates of imipenem（97.8%） and meropenem（97.8%） were the highest.Those of cefoperazone/sulbactam（87.7%）,piperacillin/tazobactam（84.4%） and amikacin（80.4%） were higher.The resistance rates of aztreonea,cefotaxime,ciprofloxacin and levofloxacin were all above 50%.Conclusion：The multi-drug resistance existed in surgical nosocomial infection causing by PAE in our hospital.We should strengthen monitoring and controlling of it.