非小细胞肺癌患者中B细胞淋巴瘤-2、人体第二表皮生长因子受体蛋白表达的比较研究

目的 研究非小细胞肺癌（NSCLC）患者B细胞淋巴瘤-2（Bcl-2）、人体第二表皮生长因子受体（Her-2）蛋白的表达情况及临床意义.方法 应用组织芯片、免疫组化技术检测208例NSCLC患者的肿瘤组织、150例癌旁组织以及17例良性肺疾病肺组织中的Bcl-2、Her-2蛋白的表达情况.结果 ①NSCLC癌组织中Bcl-2蛋白表达率明显高于癌旁组织及肺良性疾病肺组织（ P〈0.05）；Bcl-2蛋白表达水平与NSCLC临床分期及淋巴结转移有相关性（P〈0．05）.②NSCLC癌组织中Her-2蛋白的表达率明显高于癌旁组织及肺良性疾病肺组织（P〈0.05）；Her-2蛋白表达水平与NSCLC分化程度差异有统计学意义（P〈0．05）.结论 ①Bcl-2、Her-2蛋白在NSCLC组织中均高表达,提示Bcl-2及Her-2基因的表达异常与NSCLC的发生发展密切相关；②Bcl-2蛋白表达程度与NSCLC的临床分期及淋巴结转移有关,Her-2蛋白表达程度与NSCLC的分化程度有关,提示两者均与肿瘤恶性生物学行为密切相关.

The comparative study of the expressions of Bcl-2 and Her-2 protein in the patients with NSCLC

Objective To study the expressions and significances of Bcl -2 and Her -2 protein of patients with NSCLC （ non - small cell lung cancer）. Methods 208 cases of NSCLC tumor tissues, 150 cases of adjacent tissues and 17 patients with benign lung disease were detected in the lung tissues of Bcl -2 and Her -2 protein expression by the methods of tissue microarray and immunohistochemistry. Results （1）NSCLC tumor tissue expression of Bcl - 2 protein was significantly higher than in adjacent and benign lung tissues（P 〈0.05 ） ;The difference of Bcl -2 protein expression between different clinical stage and lymph node metastasis was significant （ P 〈 0.05 ）. （2）NSCLC tumor tissue expression of Her - 2 protein was significantly higher than in adjacent and benign lung tissues （ P 〈 0.01 ） ; The difference of Her - 2 protein expression with different differentiation was significant （ P 〈 0.05 ）. Conclusion （1）Bcl - 2 and Her -2 protein are highly expressed in NSCLC and associated with the development of NSCLC, so they can be used for early diagnosis of NSCLC;（2）Bcl -2 protein is associated the clinical stage and lymph node metastasis; Her- 2 protein is associated with the differentiation.