| 二硫化碳及其与噪声联合作用对大鼠心肌组织的损害 |
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| 引用本文： | 白云峰,刘斌贝,翁恩琪. 二硫化碳及其与噪声联合作用对大鼠心肌组织的损害[J]. 中华劳动卫生职业病杂志, 2001, 19(2): 95-97 |
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| 作者姓名： | 白云峰 刘斌贝 翁恩琪 |
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| 作者单位： | 华东师范大学环境科学系环境生理与毒理研究室 |
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| 摘 要： | 目的 研究二硫化碳(CS
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| 关 键 词： | 二硫化碳 噪声 脂质过氧化 心肌损害 丙二醛 心肌形态学 职业危害 |
| 修稿时间： | 2000-04-03 |
Effects of carbon disulfide exposure and combined effects with noise on rat myocardial damage |
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| BAI Yunfeng,LIU Yun,WENG Enqi. Effects of carbon disulfide exposure and combined effects with noise on rat myocardial damage[J]. Chinese journal of industrial hygiene and occupational diseases, 2001, 19(2): 95-97 |
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| Authors: | BAI Yunfeng LIU Yun WENG Enqi |
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| Abstract: | Objective To study the effects of carbon disulfide(CS2) exposure and the combined effects with noise on rat myocardium tissue. Methods After CS2 or noise,or both exposure,superoxide dismutase(SOD) activity and malonaldehyde(MDA) content were measured,and morphological changes were observed under microscope. Results After CS2 exposure(189 mg/kg),SOD activity in the myocardium was decreased from (44.36±0.43)U/mg pro to (41.78±0.51)U/mg pro(P<0.01) and MDA content increased from (2.20±0.09)nmol/mg pro to (2.72±0.27)nmol/mg pro(P<0.05).The morphological observation showed that the blood vessels were swollen,some myocardial fibers were broken and cross striation disappeared.When CS2 combined with noise,the above changes were markedly aggravated,SOD activity and MDA content were (40.21±1.01)U/mg pro and (3.99±0.28)nmol/mg pro respectively(P<0.01). Conclusion CS2 may damage the myocardium tissue,through interfering the metabolism of free radicals and enhancing the lipoperoxidation.The combination of CS2 with noise exposure have synergic effects. |
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| Keywords: | Carbon disulfide Noise Myocardium Morphology Lipoperoxidation |
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