扁平苔藓皮损中肥大细胞数和P物质的表达及其意义

目的:探讨肥大细胞和P物质在扁平苔藓发病中的作用。方法:采用组织化学和免疫组化的染色方法,检测扁平苔藓皮损中未脱颗粒的肥大细胞数和P物质的表达情况。结果:甲苯胺蓝特殊染色发现,扁平苔藓皮损中未脱颗粒的肥大细胞数(3.56±1.52)明显低于正常对照组(5.22±1.28),其差异具有统计学意义(P<0.01);免疫组化染色发现,扁平苔藓皮损中P物质的表达强度明显高于正常对照组,其差异具有统计学意义(P<0.01);采用Spearman等级相关分析,二者呈一定的负相关(rs=-0.397,P<0.05)。结论:肥大细胞和P物质在扁平苔藓的发病中可能起一定的作用。

The quantity of mast cells and the substance P expression and their significance in lichen planus

Objective: To determine the role of mast cells and substance P in the pathogenesis of lichen planus.Methods: The number of undegranulated mast cells and the expression level of substance P were detected in the lesions of lichen planus by histochemical and immunohistochemical technique.Results: Compared with normal controls,the number of undegranulated mast cells in lichen planus lesions was significantly lower(P<0.01),while the expression level of substance P was significantly higher(P<0.01).There was a negative correlation between the number of undegranulated mast cells and the expression of substance P in the lesions of lichen planus(r_s=(-0.397),P<0.05).(Conclusion): Mast cells and substance P might play a certain role in the pathogenesis of lichen planus.