血浆NT—proBNP、MYO、cTnI联合检测对诊断急性心肌梗死的临床意义

目的探讨急性心肌梗死（AMI）患者血浆N端B型脑钠肽前体（NT—proBNP）、肌红蛋白（MYO）、肌钙蛋白I（cTnI）的浓度变化及三者间的相关性。方法通过酶联荧光分析法测定60例AMI患者和48例健康对照者血浆NT-proBNP、MYO、cTnI含量并进行对照分析。结果AMI组血浆NT—proBNP、MYO、cTnI含量显著高于健康对照组，差异具有统计学意义（P〈0．05）；NT—proBNP与MYO、cTnI之间具有良好的正相关关系（r=0．715，r=0．805）；AMI组NT—proBNP、MYO、cTnI单项及三项联合检测的敏感性分别为86．67％、81．67％、83．33％和96．67％；特异性分别为89．58％、68．75％、95．83％和68．75％。结论NT—proBNP、MYO、cTnI在AMI患者中明显升高，三项联合检测可提高AMI早期诊断的敏感性。

Clinical value of combined detection of plasma NT-proBNP,MYO and cTnI in diagnosis of acute myocardial infarction

Objective To study the changes in the concentrations of plasma amino-terminal pro-brain natriuretic peptide （NT- proBNP） , myoglobin （MYO） and cardiac troponin I （eTnI） in patients with acute myocardial infarction （AMI） and the correlation among the them. Methods Plasma NT-proBNP, MYO and eTnI were determined by enzyme-linked fluorescence analysis in 60 AMI patients （ AMI group） and 48 healthy controls （ control group）. Results The levels of NT-proBNP, MYO and eTnI were sig- nificantly higher in AMI group than in control group （ P 〈 0.05 ）. In AMI group, a significantly positive correlation was found be- tween NT-proBNP and each of MYO and eTnI （ r = 0. 715, r = 0. 805 ）. The sensitivity of single NT-proBNP, MYO, cTnI and com- bined detection in AMI diagnosis was 86.67% , 81.67% , 83.33% and 96.67% , and the specificity was 89.58% , 68.75% , 95.83% and 68.75% , respectively. Conclusion The levels of NT-proBNP, MYO and eTnI are significantly higher in AMI. Combined detection helps to improve the detection sensitivity of AMI in early diagnosis.