| 甲硝唑磷酸二钠与乳酸环丙沙星注射液配伍稳定性研究 |
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| 引用本文： | 罗艳,颜怀城,伍文星.甲硝唑磷酸二钠与乳酸环丙沙星注射液配伍稳定性研究[J].中国药业,2007,16(15):15-15. |
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| 作者姓名： | 罗艳 颜怀城 伍文星 |
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| 作者单位： | 1. 中国人民解放军总医院第一附属医院药剂药理科,北京,100037
2. 第三军医大学学员旅,重庆,400038 |
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| 摘 要： | 目的 观察甲硝唑磷酸二钠与乳酸环丙沙星注射液配伍后的变化,为临床应用提供参考依据.方法 用薄层层析法分析配伍后析出的沉淀物,用酸碱滴定法测定二者析出沉淀的pH条件.结果 甲硝唑磷酸二钠在pH值为1.92时生成白色沉淀,乳酸环丙沙星注射液pH值为5.56时生成白色沉淀;二者混合后pH值为5.76时会析出乳酸环丙沙星沉淀.结论 甲硝唑磷酸二钠与乳酸环丙沙星注射液存在配伍禁忌.
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| 关 键 词： | 甲硝唑磷酸二钠 乳酸环丙沙星 配伍禁忌 薄层层析 |
| 文章编号： | 1006-4931（2007）15-0015-01 |
| 修稿时间： | 2007-05-02 |
Chemical Incompatibility Between Arilin Disodium Hydrogen Phosphate and Ciprofloxacin |
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| Luo Yan,Yan Huaicheng,Wu Wenxing.Chemical Incompatibility Between Arilin Disodium Hydrogen Phosphate and Ciprofloxacin[J].China Pharmaceuticals,2007,16(15):15-15. |
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| Authors: | Luo Yan Yan Huaicheng Wu Wenxing |
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| Institution: | 1. Department of Pharmacy and Pharmacology, First Affiliated Hospital, General Hospital of PLA, Beijing, China 100037; 2. Student Division, Third Military Medical University, Chongqing, China 400038 |
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| Abstract: | Objective To observe the changes after mixing of arilin disodium hydrogen phosphate injection and ciprofloxacin injection and to provide references for clinical application. Methods Thin layer chromatography was used to analyze the deposition after mixing of arilin disodium hydrogen phosphate injection and ciprofloxacin injection. Acid-base titration was used to determine the pH condition and educing deposition. Results Ciprofloxacin injection educed white deposition when pH value was 5.56, while arilin disodium hydrogen phosphate injection educed white deposition when pH value was 1.92. pH value was 5.76 after mixing deposition of ciprofloxacin educed. Conclusion There exists chemical incompatibility between arilin disodium hydrogen phosphate injection and ciprofloxacin injection. |
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| Keywords: | arilin disodium hydrogen phosphate ciprofloxacin chemical incompatibility thin layer chromatography |
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