| 丹参对肝脏缺血再灌注损伤的保护作用 |
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| 引用本文： | 刘剑仑,蓝瑚.丹参对肝脏缺血再灌注损伤的保护作用[J].昆明医学院学报,1994,15(1):29-31. |
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| 作者姓名： | 刘剑仑 蓝瑚 |
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| 作者单位： | 昆明医学院第二附属医院肝胆外科，广西医科大学附属肿瘤医院 |
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| 摘 要： | 钳闭肝脏左中叶，造成肝脏缺血—再灌注损伤模型，观察丹参的保护效果。结果肝脏缺血再灌注时，肝组织内丙二醛（ＭＤＡ）和Ｃａ２＋含量增加，且缺血时间愈长，改变愈明显，肝脏损害愈严重，恢复愈慢。预先给予丹参能显著减轻上述改变。表明丹参抗氧化及防止细胞内Ｃａ２＋超负荷是其保护缺血再灌注肝脏的重要机制．
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| 关 键 词： | 丹参 肝脏缺血 再灌注损伤 丙二醛 |
Protection of Redix Salviae Miliorrhazae on Hepatic Ischemia/Reperfusion Injury |
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| Liu Jianlun, Lan Hu, Wang Binghuang, Zhang Bingyan.Protection of Redix Salviae Miliorrhazae on Hepatic Ischemia/Reperfusion Injury[J].Journal of Kunming Medical College,1994,15(1):29-31. |
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| Authors: | Liu Jianlun Lan Hu Wang Binghuang Zhang Bingyan |
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| Abstract: | A study was undertaken to observe and assess protection of redix salviae miliorrhazae (RSM) on hepatic ischemia/reperfusion injury of rats in the left and median lever lobers.The results show that MDA and Ca2+in hepatic tissue gradually increased, The longer the hepatic lasted, the more serious the hepatic cellular injury was.Pre reatment with RSM can make the changes much less significant.The data suggest that protection of RSM against hepatic ischemia /reperfusion injury is due to antagonizing lipid peroxide and preventing overload of intracellular Ca2+. Used to work in Kunming Medical College. Now a staff of the Affiliated Tumour Hospital,Guxi Medical University |
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| Keywords: | RSM Hepatic reperfusion injury MDA Ca2+ |
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