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Preferential Localization of Human CD5+ B Cells in the Peritoneal Cavity
Authors:S. NISITANI,M. MURAKAMI,T. AKAMIZU,T. OKINO,K. OHMORI,T. MORI,M. IMAMURA,&   T. HONJO
Affiliation:;Department of Medical Chemistry,;Department of Laboratory Medicine,;Department of Medicine and Clinical Science,;Department of Surgery and Surgical Basic Science, Faculty of Medicine, Kyoto University, Kyoto, Japan
Abstract:In a transgenic mouse model of autoimmune haemolytic anaemia, CD5+ B lymphocytes localized in the peritoneal cavity are shown to play an important role in the onset of autoimmune disease. The authors have examined whether CD5+ B cells are present in the peritoneal cavity of 12 human individuals with non-invasive gastrointestinal tumours and found that in humans CD5+ B cells preferentially lodge in the peritoneal cavity as compared to the peripheral blood and spleen while the numbers of the peritoneal B lymphocytes in humans are much lower than in mice and vary widely between individuals.
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