| MMC对兔眼滤过道成纤维细胞活性的抑制作用 |
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| 引用本文： | 赵俊宏,孙乃学,苏宝山,王建明,王智鹏. MMC对兔眼滤过道成纤维细胞活性的抑制作用[J]. 眼科研究, 2001, 19(2): 114-115 |
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| 作者姓名： | 赵俊宏 孙乃学 苏宝山 王建明 王智鹏 |
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| 作者单位： | 1. 西安交通大学第二医院眼科 710004
2. 西安交通大学第二医院病理科 710004 |
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| 基金项目： | 本课题受陕西省自然科学基金资助(项目编号:96SM42) |
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| 摘 要： | 目的：应用细胞增殖指标核仁组成区相关嗜银蛋白（AgNORs)，研究兔眼滤过道成纤维细胞（Fb)增殖规律及丝裂霉素C（MMC）的抗增殖作用，并对其临床意义进行探讨。方法：邓兔眼滤过道切片作AgNORs及HE染色，比较MMC眼和对照眼Fb AgNORs染色颗粒数量。结果：不同手术区MMC眼Fb AgNORs颗粒数显著低于对照眼，MMC抑制率为50.7%-82.1%。结论：丝裂毒素C可以有效抑制咬切口、巩膜瓣下、结膜瓣下Fb的增殖活性，抑制作用稍强于同类药物5-Fu。
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| 关 键 词： | 滤过术 成纤维细胞 兔 丝裂霉素C 青光眼 AgNORs MMC |
| 修稿时间： | 2000-09-13 |
The effects of subscleral mitomycin C on filtration path fibroblasts in rabbit eyes |
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| Zhao Junhong,Sun Naixue,Su Baoshan,et al.. The effects of subscleral mitomycin C on filtration path fibroblasts in rabbit eyes[J]. Chinese Ophthalmic Research, 2001, 19(2): 114-115 |
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| Authors: | Zhao Junhong Sun Naixue Su Baoshan et al. |
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| Abstract: | Objective To investigate the regularity of fibroblast (Fb) proliferation and the effect of Mitomycin C(MMC) after filtration surgery in rabbits. MethodsHistochemistry method of AgNORs and HE was used to count the Fb AgNORs granules of MMC eyes and control eyes.ResultsThe AgNORs granules were statistically different between MMC eyes and control eyes,the suppressive rate was from 50.7% to 82.1%.ConclusionMMC can suppress effectively the activity of Fb which proliferated in sclerectomy area, subscleroflap area and subconjunctivoflap area . |
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| Keywords: | filtration surgery fibroblast rabbits MMC |
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