A synergic inhibitory-effect of combination with selective cyclooxygenase-2 inhibitor and S-1 on the peritoneal metastasis for scirrhous gastric cancer cells |
| |
Authors: | Tendo Masashige Yashiro Masakazu Nakazawa Kazunori Yamada Nobuya Sawada Tetsuji Ohira Masaichi Hirakawa Kosei |
| |
Affiliation: | Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. |
| |
Abstract: | An inhibitory-effect of a selective cyclooxygenase-2 (COX-2) inhibitor on peritoneal metastasis of scirrhous gastric carcinoma was investigated in vivo. Peritoneal metastasis had developed after intraperitoneal inoculation of scirrhous gastric cancer cells, OCUM-2MD3, in nude mice. COX-2 inhibitor and/or S-1 were administered orally in nude mice with peritoneal metastasis. Oral administration of COX-2 inhibitor and S-1 significantly prolonged survival rates of these nude mice, compared with either alone. These findings suggested that combining S-1 and COX-2 inhibitor administration obtain a synergistic inhibitory-effect on the peritoneal metastasis of scirrhous gastric carcinoma. |
| |
Keywords: | COX-2 inhibitor Peritoneal metastasis Scirrhous gastric cancer JTE-522 S-1 |
本文献已被 ScienceDirect PubMed 等数据库收录! |