The effect of a modified etidronate cyclical regimen on postmenopausal osteoporosis: A four-year study |
| |
Authors: | G. P. Lyritis N. Tsakalakos I. Paspati Gr. Skarantavos A. Galanos C. Androulakis |
| |
Affiliation: | (1) Laboratory for the Research of Musculoskeletal System, University of Athens, KAT Hospital, Kifissia 145 61, Athens, Greece |
| |
Abstract: | Summary To develop an improved treatment schedule for osteoporosis, a study was undertaken in 100 postmenopausal women using a modified ADFR 90-day cyclical regimen with etidronate. After one year of treatment, the etidronate-treated group showed a significant increase in bone density of the spine, which continued over the following 2 years of treatment and remained stable during the fourth year. In contrast, in the non-etidronate group, bone density decreased significantly after four years. In addition, the fracture rate was significantly lower in the etidronate group than in the non-etidronate group. Side effects were minimal in both groups and no serious adverse reactions were reported. In conclusion, it appears that a cyclical regimen using 1,25-dihydroxyvitamin D3, etidronate and calcium increases bone mass and reduces fractures with no significant side effects, thus making a useful contribution in the treatment of postmenopausal osteoporosis. |
| |
Keywords: | Bone Mineral Density Etidronate 1,25-dihydroxyvitamin D3 Postmenopausal Osteoporosis |
本文献已被 SpringerLink 等数据库收录! |
|