| 高胆固醇上调Caveolin-1的表达 |
| |
| 引用本文： | 冉胤威,杜俊蓉,白波,张蓉,钱忠明. 高胆固醇上调Caveolin-1的表达[J]. 生物医学工程学杂志, 2004, 21(2): 276-279 |
| |
| 作者姓名： | 冉胤威 杜俊蓉 白波 张蓉 钱忠明 |
| |
| 作者单位： | 1. 四川大学,华西药学院,药理教研室,成都,610041
2. 香港理工大学,应用生物及化学科技学系,中国香港 |
| |
| 基金项目： | 国家自然科学基金资助项目 (3 70 0 90 0 ) |
| |
| 摘 要： | 为了研究高胆固醇血症对血管内皮细胞膜上 Caveolin- 1表达的影响。用免疫组织化学的方法检测了高胆固醇血清刺激的培养人脐静脉内皮细胞株 ECV- 30 4细胞以及高脂血症大鼠动脉内皮上 Caveolin- 1表达量的动态变化。发现高胆固醇可上调体内外内皮细胞膜上 Caveolin- 1的表达。在高血脂模型初期 ,Caveolin- 1的表达量与高血脂水平的维持时程成正相关 ;在高胆固醇血症模型后期 ,血管内皮细胞膜上 Caveolin- 1的表达略有下降
|
| 关 键 词： | 胞膜窖 窖蛋白 高胆固醇血症 免疫组织化学 |
High Cholesterol Level Upregulate the Expression of Caveolin-1 |
| |
| Yinwei Ran,Junrong Du,Bo Bai,Rong Zhang,Zhongmin Qian. High Cholesterol Level Upregulate the Expression of Caveolin-1[J]. Journal of biomedical engineering, 2004, 21(2): 276-279 |
| |
| Authors: | Yinwei Ran Junrong Du Bo Bai Rong Zhang Zhongmin Qian |
| |
| Affiliation: | Department of Pharmacology, West China School of Pharmacy of Sichuan University, Chendu 610041, China. |
| |
| Abstract: | To study the influence of hypercholesterolemia with caveolin 1 on the plasmalemma of vascular endothelium,we used the methods of immunohistochemistry to detect the dynamic changes of caveolin 1 in cultured ECV 304 cells which were stimulated high cholesterol serum and the arterial endothelium of hypercholesterolemia rats. It is resulted that high cholesteorol level can upregulate the expression of caveolin 1 both in vitro and in vivo. In the initial stage of hypercholesterolemia model,the expression of caveolin 1 increased as the time of high cholesterol level added,but in the later period it was decreased slightly. |
| |
| Keywords: | Caveolea Caveolin 1 Hypercholesterolemia Immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
