| 口占吨氢醇比色法用于红霉素片溶出度中的定量测定 |
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| 引用本文： | 乐健,仇士林,陈从恒. 口占吨氢醇比色法用于红霉素片溶出度中的定量测定[J]. 中国药学杂志, 1999, 0(8) |
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| 作者姓名： | 乐健 仇士林 陈从恒 |
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| 作者单位： | 上海市药品检验所 |
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| 摘 要： | 目的：红霉素片溶出度中的定量测定。方法：以口占吨氢醇比色法用于红霉素片溶出度中的定量测定，并与药典上原有的方法进行了比较，讨论了口占吨氢醇试剂的浓度、反应温度、时间和冷却方法等因素对结果的影响。结果：定量测定回归方程中ｒ＝０．９９９７，线性范围为９０．９４９～１８１．８９８单位／ｍｌ，测定原料的回收率为９９．８６％，测定片剂的回收率１００．０５％。结论：新方法准确度和精密度均较好。
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| 关 键 词： | 占吨氢醇比色法；红霉素片；溶出度 |
Quantitative determination of erythromycin tablet in dissolution test using xanthydrol colorimetery |
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| Le Jian. Quantitative determination of erythromycin tablet in dissolution test using xanthydrol colorimetery[J]. Chinese Pharmaceutical Journal, 1999, 0(8) |
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| Authors: | Le Jian |
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| Abstract: | OBJECTIVE: To develop an assay for the quantitative determination of erythromycin tablet in its dissolution test. METHODS: Xanthydrol colorimetry was used for the quantitative determination of erythromycin tablet in its dissolution test.It was compared with the original methods in pharmacopoeia.The influence of xanthydrol reagent concentration,reaction temperature and time and cooling method were also discusssed. RESULTS: The linear range was over 90.949181.898 unit/ml with the correlation coefficient 0.9997.The recoveries of erythromycin and its tablet were 99.86% and 100.05%,respectively. CONCLUSION: The new method showed more accurate and precise than the original one. |
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| Keywords: | xanthydrol colorimetry erythromycin tablet dissolution |
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