西酞普兰与帕罗西汀治疗焦虑抑郁共病临床对照观察

目的比较西酞普兰与帕罗西汀对焦虑抑郁共病治疗的有效性和安全性。方法收集焦虑抑郁共病患者50例，随机分为两组，分别给予西酞普兰和帕罗西汀单盲对照治疗6周。采用17项汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）和不良反应量表（TESS）评定疗效及安全性。结果两组总体疗效差异无统计学意义，治疗第2周两组HAMD、HAMA总分均有显著下降（P〈0．01），且不良反应少。结论西酞普兰与帕罗西汀治疗焦虑抑郁共病疗效相当，安全性高，而西酞普兰不良反应更轻一些。

A clinical comparative study between dtalopram and paroxetine in treating the depression patients with anxiety

Objective To compare the efficacy and safety of citalopram and paroxetine in treating the depression patients with anxiety. Methods Fifty depression patients with anxiety were randomly divided into two groups and treated with citalopram and paroxetine for six weeks respectively. The efficacy was assessed by HAMD, HAMA and the safety by TESS. Results The clinical efficacy in the two groups had no significant difference. At the end of the 2nd week of treatment, the HAND and liANA scores of both groups lowered very significantly （P 〈 0. 01 ）, with few adverse reaction. Conclusion Citalopram is as effective and safe as paroxetine in treating the depression patients with anxiety and have higher safety, but citalopram has fewer untoward reactions.