醋氨己酸锌治疗胃溃疡的作用机制的探讨

目的 :测定胃溃疡病人胃粘膜中前列腺素E2 (PGE2 )、氨基己糖含量 ,以探讨醋氨己酸锌治疗胃溃疡的作用机制。方法 :12 4例病人分为对照组60例 ,给予奥美拉唑 2 0mg ,每晨 1次口服 ,共 4wk ,同时服用阿莫西林 1g ,bid ,甲硝唑 0 .4 g ,bid ,共 1wk ;治疗组 64例 ,除同样服用上述 3种药物外 ,加服醋氨己酸锌 30 0mg ,tid ,4wk为一个疗程。结果 :治疗组胃溃疡治愈率 ( 94 %)明显优于对照组 ( 80 %) ,P <0 .0 5。治疗组治疗后PGE2 含量为 ( 2 .8±s 0 .6) μg·mg- 1组织 ,明显高于治疗前[( 1.4± 0 .3) μg·mg- 1组织 ](P <0 .0 1) ,而对照组则无明显变化 ,分别为 ( 1.4± 0 .4 ) μg·mg- 1组织和( 1.4± 0 .3) μg·mg- 1组织。治疗组治疗后氨基己糖水平为 ( 18.6± 2 .6) μg·mg- 1组织 ,明显高于治疗前[( 14.2± 2 .4 ) μg·mg- 1组织 ],P <0 .0 1,而对照组则无明显变化 ,分别为 ( 14.4± 2 .5 ) μg·mg- 1组织和( 15± 4 ) μg·mg- 1组织。结论 :醋氨己酸锌可提高胃粘膜中PGE2 、氨基己糖含量 ,减轻胃粘膜损伤 ,促进胃溃疡愈合。

Probing of effect mechanism of zinc acexamate in treating gastric ulcer

AIM: To prove into the effect mechanism of zinc acexamate in treating gastric ulcer by determinating the gastric mucosal levels of prostaglandin E 2 (PGE 2) and hexosamine. METHODS: The control group, sixty patients whom were divided from one hundrend and twenty-four patients with active gastric ulcer and Hp positive, was administered omeprazole 20 mg in the morning for 4 wk, moxicillin 1.0 g, bid, and metronidazole 400 mg, bid for 1 wk. The treatment group, sixty-four patients besides using the above mentioned 3 drugs, zinc acexamate 300 mg, tid was added orally for 4 wk. RESULTS:The cured rate of treatment group (94 %) was better than that of the control group (80 %)(P<0.05).PGE 2 determination: The gastric mucosal levels increased significantly (2.8+ s 0.6)μg·mg -1 tissue as compared with that before treatment (( 1.4± 0.3)μg·mg -1tissue) in the treatment group, and had no siginificant difference ((1.4± 0.4)μg·mg -1 tissue) vs ((1.4±0.3)·μg·mg -1 tissue)in control group. Hexosamine determination: the gastric mucosal levels increased significantly ((18.6±2.6) μg·mg -1 tissue) as compared with that before treatment ((14.2± 2.4)μg·mg -1 tissue) in the treatment group,and had no siginificant difference ((14.4±2.5)μg·mg -1 tissue) vs ((15+4)μg·mg -1 tissue), in control group. CONCLUSION: Zinc acexamate can increase the gastric mucosal levels of PGE 2 and hexosamine , prevent the injury of gastric mucosa, and promote the healing of ulcer.