A potential role for arginase in recurrent infections and hypertrophy of tonsillar and adenoidal tissue |
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Authors: | S Elgün K Güney M Tuncer I H Gökhun |
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Institution: | (1) Ankara University Faculty of Medicine, Department of Biochemistry, Ankara, Turkey, TR;(2) Ankara Numune Hospital, ENT Clinic, Ankara, Turkey, TR;(3) Ankara üniversitesi Tip Fakültesi, Biokimya A.B.D., Dekanlik Binasi, Sihhiye 06100, Ankara, Turkey e-mail: elgun@tr-net.net.tr, Tel.: +90 312 418 4570, Fax: +90 312 310 6370, TR |
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Abstract: | Since arginase has been found to be an arginine-depleting and nitric oxide synthase-regulating enzyme, the present study
was devised to examine hypertrophied and infected tonsil and adenoid arginase activity in relation to a metabolic arginase-nitric
oxide pathway and its association with disease processes. Tissues were taken from 32 children undergoing adenotonsillectomy.
There was a statistically significant difference between the two tissue enzyme activities, with tonsillar arginase activity
being higher than the corresponding adenoidal tissue (P < 0.005). This suggests a potential role for tissue arginase activity as an outcome module and a contributing factor in chronic
recurrent infection and hypertrophy of tonsillar and adenoidal tissues.
Received: 8 October 1998 / Accepted: 22 April 1999 |
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Keywords: | Arginase Tonsillitis Tonsillar and ?adenoidal hypertrophy |
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