中药配合氦氖激光治疗黄褐斑的疗效评价及对一氧化氮影响

目的:观察中药、川芎嗪配合氦氖激光对黄褐斑患者一氧化氮(NO)的影响及疗效。方法:90例黄褐斑患者随机分为两组:治疗组54例,采用自拟补肾疏肝化瘀方、川芎嗪配合氦氖激光治疗;对照组36例,采用口服维生素E、维生素C,20%壬二酸霜外涂治疗。治疗组治疗前均检测NO,并与30例健康人对照;治疗组有33例治疗后检测NO,并与治疗前对比。结果:治疗组54例,基本治愈17例,显效26例,总有效率79.6%,明显优于对照组(P<0.05)。黄褐斑患者NO检测明显高于健康对照组(P<0.05)。经中药、川芎嗪配合氦氖激光治疗后,NO明显降低(P<0.01)。结论:黄褐斑患者存在氧化与抗氧化失衡;自拟补肾疏肝化瘀方、川芎嗪配合氦氖激光治疗黄褐斑,具有抗氧化、降低NO自由基等作用,临床治疗获得较好疗效。

Effect of Chinese herbal medicine, Ligustrazin, in combination with He -Ne Laser on NO level and its efficacy in treating patients with chloasma

Objectives:To observe the effect of Chinese herbal medicine,Ligustrazin,in combination with He-Ne Laser on NO level and the therapeutic efficacy in treating patients with chloasma.Methods:Ninety patients were randomly divided into two groups,54 patients in the treatment group were treated with Chinese herbal medicine,Ligustrazin,in combination with He-Ne Laser.The other 36 patients in the control group were treated with Vit E,Vit C and 20% azelaic acid cream.The NO level was measured for all the 54 patients in treatment group before therapy,among them,33 patients also received post-therapy NO level testing.Results:17 patients were cured in the treatment group,significant improvement was seen in 26 patients.The total effective rate was 79.6% and it was significantly higher than that in the control group(P<0.05).The NO level was higher in chloasma group as compared with the healthy controls(P<0.05).Decrease of NO level was found in 33 patients after the therapy(P<0.01%).Conclusions:Imbalance between oxidation and antioxidation were found in the patients with chloasma.Chinese herbal medicine,Ligustrazin,in combination with He-Ne Laser were effective in decreasing the NO level and were clinically effective in treating chloasma.