丙酸氟替卡松雾化吸入及孟鲁司特治疗婴幼儿喘息的临床观察

①目的探讨丙酸氟替卡松和孟鲁司特对婴幼儿喘息的临床疗效。②方法将在我院门诊或病房收治的喘息性婴幼儿300例选为研究对象，除去失访及没有坚持用药的患者，成功随访132例。132例患儿按照所用药物不同分为丙酸氟替卡松组和孟鲁司特组，丙酸氟替卡松组70例，男30例，女40例，年龄（13．2＆#177;5．05）月；孟鲁司特组62例，男25例，女37例，年龄（13．5＆#177;4．99）月。观察两组在1年内平均出现喘息的次数和无症状天数。③结果两组平均喘息次数存在显著差异（ P ＜0．05），丙酸氟替卡松组无症状天数（348．6＆#177;19．3）天，高于孟鲁司特组无症状天数（321．6＆#177;34．8）天（ P ＜0．05）；两组患儿与同龄儿童相比生长速度无显著差异。④结论使用丙酸氟替卡松预防婴幼儿喘息疗效优于孟鲁司特，且不影响婴幼儿生长发育。

Effect of fluticasone propionate and montelukast in prevention of wheezing in infants

Objective To explore effect of fluticasone propionate and Montelukast in prevention of wheezing in infants . Methods Study of 300 wheezing in infants cured in our hospital ,132 cases finished the follow -ups ,they were divided into two groups;70 children in Fluticasone propionate group including male 30,femal 40 with an average of （13.2 ＆#177;5.05） M,62 children in Montelukast group including male 62 including male 25,femal 37 with an average age of （13.5 ＆#177;4.99）M.The frequency of wheez-ing recurrence and days without symptoms were observed in the two groups .Resutls There was significant difference in frequency of wheezing recurrence between 2 groups （ P ＆lt;0.05）.Fluticasone propionate group has more days without symptoms than Montelukast group,（13.5 ＆#177;4.99）vs（321.6 ＆#177;34.8）, P ＆lt;0.05.There was no significant difference in growth rate between two groups and nor-mal children .Conclusion Fluticasone propionate is more effective than montelukast in prevention of wheezing in infants and has no effect in infant growth and development .