| 内源性大麻素系统与心肌缺血再灌注损伤 |
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| 引用本文： | 王鹏飞 综 述,何 奔 审 校.内源性大麻素系统与心肌缺血再灌注损伤[J].中国动脉硬化杂志,2010,18(8):669-672. |
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| 作者姓名： | 王鹏飞 综 述 何 奔 审 校 |
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| 作者单位： | 上海交通大学医学院附属仁济医院心内科， 上海市 200127 |
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| 摘 要： | 心肌缺血再灌注损伤与氧化应激、炎症反应和钙超载有关,仍然是心血管领域面临的一个持续性挑战.最近研究显示,在动物心肌缺血再灌注中内源性大麻素系统对氧化应激损伤、炎症反应具有一定的抑制效应,同时还能保护内皮细胞功能,对减少心肌梗死面积,提高心肌梗死后心室复苏能力和改善预后具有重要作用.文章就内源性大麻素系统与心肌缺血再灌注损伤的关系做一综述.
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| 关 键 词： | 内源性大麻素系统 大麻素受体 心肌梗死 缺血再灌注损伤 氧化应激 |
| 收稿时间： | 2010/5/14 0:00:00 |
| 修稿时间： | 2010/6/21 0:00:00 |
The Endocannabinoid System and Myocardial Ischemia-Reperfusion Injury |
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| WANG Peng-Fei,and HE Ben.The Endocannabinoid System and Myocardial Ischemia-Reperfusion Injury[J].Chinese Journal of Arteriosclerosis,2010,18(8):669-672. |
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| Authors: | WANG Peng-Fei and HE Ben |
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| Institution: | Department of Cardiology,Renji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200127 |
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| Abstract: | Myocardial ischemic-reperfusion injury is related to oxidative stress,inflammatory responses and calcium overload,which is still a continuing challenge in cardiovascular field.Recent findings in animal model shows that synthetic and endogenous cannabinoids can decrease oxidative stress,attenuate inflammatory responses and protect endothelial function,which play an important role in decreasing the infarct size,promoting ventricular functional recovery and increasing the survival rate.Here,we will overview the relationship between endocannabinoid system and myocardial ischemia-reperfusion injury. |
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| Keywords: | Endocannabinoid System Cannabinoid Receptors Myocardial Infarction Ischemia-Reperfusion Injury Oxidative Stress |
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